Tissue Affinity and Bioabsorption to Fine Calcium Carbonate Particles

• NISHIKAWA Tetsunari

  Department of Oral Pathology,

• OKAMURA Tomoharu

  Department of Oral Pathology,

• TOMINAGA Kazuya

  Department of Oral Pathology,

• WATO Masahiro

  Department of Oral Pathology,

• KURIOKA Kagami

  First Department of Oral and Maxillofacial Surgery,

• MORITA Shosuke

  First Department of Oral and Maxillofacial Surgery,

• IMAI Koichi

  Department of Biomaterials, Osaka Dental University, Osaka, Japan

• MIYAKE Tatsuro

  Department of Oral Health Sciences, Faculty of Nursing and Health Care, Baika Women's University, Osaka, Japan

• TANAKA Akio

  Department of Oral Pathology,

抄録

The scaffold material for the bone formation in the defect must be bioabsorptive. The calcium mineral of the scaffold is used for newly formed bone. In this study, we clarified the tissue affinity and bioabsorption to three kinds of novel fine calcium carbonate particles, LUMINUS, CUBE-18BH and WHISCAL. These particles were added into cell culture, and the mitochondrial activity of culture cell was calculated. These particles were then implanted under the dorsal skin of the rats, and were histopathologically observed.Five days after addition of the particles, there was no decrease in the mitochondrial activity. The implanted particles had completely disappeared with macrophages, without neutrophils. These kinds of fine calcium carbonate particles were bioabsorbable materials with few inflammatory reactions and were thought to be a useful scaffold for bone formation.

収録刊行物

• Nano Biomedicine

  Nano Biomedicine 7 (1), 21-27, 2015

  ナノ・バイオメディカル学会

キーワード

• bioabsorption
• lymphocytes
• macrophages
• calcium particles

詳細情報

• CRID: 1390001205344231680
• NII論文ID: 130005150627
• DOI: 10.11344/nano.7.21
• ISSN: 21854734
• ISSN: 18835198
• Web Site: https://search.jamas.or.jp/link/ui/2016110788
• 本文言語コード: en
• データソース種別:
  • JaLC
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可