生物活性縮環天然物の全合成におけるラジカル環化戦略

• 好光 健彦

  大阪大学薬学研究科創成薬学専攻

書誌事項

タイトル別名

• Radical Cyclization Strategies in Total Syntheses of Bioactive Fused Cyclic Natural Products
• セイブツ カッセイシュクカン テンネンブツ ノ ゼン ゴウセイ ニ オケル ラジカルカンカ センリャク

抄録

The present article discusses our recent endeavors on natural product syntheses wherein radical reactions are strategically employed to access fused carbocycles. Particular emphasis is placed on the radical cyclizations that made it possible to establish the unique bond connectivity and functionalities of the target natural products. The radical chemistry-based approaches to platencin and clavilactone B are discussed here to show the utility of titanocene(III)-mediated epoxy enone cyclization, decarboxylative radical cyclization of an alkynyl carboxylic acid derivative with lead(IV) in 1,4-dioxane, and samarium(II)-mediated radical cyclization-fragmentation of an unsaturated keto ester, all of which serve as versatile means to elaborate the natural products.

収録刊行物

• 有機合成化学協会誌

  有機合成化学協会誌 74 (4), 350-359, 2016

  公益社団法人 有機合成化学協会

キーワード

• radical cyclization
• total synthesis
• bioactive natural products
• titanocene(III) chloride
• lead tetraacetate
• decarboxylation
• hydrogen transfer
• samarium diiodide
• fragmentation

詳細情報

• CRID: 1390282680318213248
• NII論文ID: 130005150747
• NII書誌ID: AN0024521X
• DOI: 10.5059/yukigoseikyokaishi.74.350
• ISSN: 18836526
• ISSN: 00379980
• NDL書誌ID: 027280560
• Web Site: http://id.ndl.go.jp/bib/027280560
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I027280560
• Web Site: https://www.jstage.jst.go.jp/article/yukigoseikyokaishi/74/4/74_350/_pdf
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可