Improvement of gait and coordinated movement by forced gait training in cerebellar ataxic B6-wob/t mice

• Beppu Hidehiko

  Fujita Memorial Nanakuri Institute, Fujita Health University

• Takayanagi Naoki

  Department of Nutrition, School of Health and Nutrition, Tokaigakuen University

• Tomita Yutaka

  Fujita Memorial Nanakuri Institute, Fujita Health University

• Mizutani Kenmei

  Fujita Memorial Nanakuri Institute, Fujita Health University

• Orand Abbas

  Fujita Memorial Nanakuri Institute, Fujita Health University

• Tamai Ikuko

  Fujita Memorial Nanakuri Institute, Fujita Health University

• Takahashi Hisahide

  ex-Education and Research Center of Animal Models for Human Diseases, Fujita Health University

• Sonoda Shigeru

  Fujita Memorial Nanakuri Institute, Fujita Health University Department Rehabilitation Medicine II, School of Medicine, Fujita Health University

抄録

Beppu H, Takayanagi N, Tomita Y, Mizutani K, Orand A, Tamai I, Takahashi H, Sonoda S. Improvement of gait and coordinated movement by forced gait training in cerebellar ataxic B6-wob/t mice. Jpn J Compr Rehabil Sci 2015; 6: 64-70.<br>Objective: The effect of forced gait training was investigated in cerebellar ataxic mice (B6-wob/t) using gait analysis and a rota-rod test.<br>Methods: B6 and B6-wob/t mice were divided into non-exercise (NEx) and exercise (Ex) groups. The Ex group received forced gait training with a running wheel at 2 m/min for 50 minutes, three times a day, six days a week, for 12 weeks. The rota-rod test was performed every 4 weeks during this period, and gait was evaluated using our pelvic axis-based gait analysis method (pelvic axis method) when a significant difference was noted between the NEx and Ex groups. The multiple comparison test was used for statistical analysis.<br>Results: After gait training for 12 weeks, the time until falling in the rota-rod test was significantly extended to 115 seconds in the Ex group compared to that (90 seconds) in the NEx group, and the hindlimb step width measured using the pelvic axis method was significantly narrower in the EX than NEx group.<br>Conclusion: Forced gait training may be effective for ataxic symptoms of B6-wob/t. The combination of the pelvic axis-based gait analysis and rota-rod test was useful to evaluate the improvement of ataxia.

収録刊行物

• Japanese Journal of Comprehensive Rehabilitation Science

  Japanese Journal of Comprehensive Rehabilitation Science 6 (0), 64-70, 2015

  一般社団法人 回復期リハビリテーション病棟協会

キーワード

• cerebellar ataxia
• B6-wob/t mouse
• forced running wheel exercise
• pelvic axis-based gait analysis
• rota-rod test

詳細情報

• CRID: 1390001205362580480
• NII論文ID: 130005151582
• DOI: 10.11336/jjcrs.6.64
• ISSN: 21855323
• Web Site: https://www.jstage.jst.go.jp/article/jjcrs/6/0/6_64/_pdf
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
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