Cytotoxicity of zinc, copper and rhodium complexes with 1,10-phenanthroline or 2,9-dimethyl-1,10-phenanthroline in cultured vascular endothelial cells

• Hara Takato

  Faculty of Pharmaceutical Sciences, Tokyo University of Science

• Matsuzaki Hiroka

  Faculty of Pharmaceutical Sciences, Tokyo University of Science

• Nakamura Takehiro

  Faculty of Pharmaceutical Sciences, Tokyo University of Science

• Yoshida Eiko

  Faculty of Pharmaceutical Sciences, Tokyo University of Science

• Ohkubo Takanori

  Department of Chemistry, Faculty of Science, Tokyo University of Science

• Maruyama Hiroki

  Department of Chemistry, Faculty of Science, Tokyo University of Science

• Yamamoto Chika

  Department of Environmental Health, Faculty of Pharmaceutical Sciences, Toho University

• Saito Shinichi

  Department of Chemistry, Faculty of Science, Tokyo University of Science Division of Bio-organometallics, Research Institute for Science and Technology, Tokyo University of Science

• Kaji Toshiyuki

  Faculty of Pharmaceutical Sciences, Tokyo University of Science Division of Bio-organometallics, Research Institute for Science and Technology, Tokyo University of Science

抄録

Organic-inorganic hybrid molecules, which have organic structure and metal atoms, can exhibit various biological activities that are distinctly different from their components. Consequently, organic-inorganic hybrid molecules are considered an effective tool to analyze biological systems. Herein, we investigated the cytotoxicity of zinc, copper, and rhodium complexes, with either 1,10-phenanthroline or 2,9-dimethyl-1,10-phenanthroline as a common ligand, in cultured vascular endothelial cells. The copper complexes, that is, dichloro(1,10-phenanthroline) copper and dichloro(2,9-dimethyl-1,10-phenanthroline) copper, exhibited high cytotoxicity accompanied by considerable accumulation inside the cells. Potassium tetrachloro(1,10-phenanthroline) rhodate also exhibited cytotoxicity and considerable accumulation. Thus, it was found that the cytotoxicity of organic-inorganic hybrid molecules to vascular endothelial cells depends on the interaction between the intramolecular metal and ligand, which facilitates their uptake by the cells.

収録刊行物

• Fundamental Toxicological Sciences

  Fundamental Toxicological Sciences 3 (3), 109-113, 2016

  一般社団法人 日本毒性学会

キーワード

• Bio-organometallics
• Coordination compound
• 1,10-Phenanthroline
• Cytotoxicity
• Metal
• Vascular endothelial cell

詳細情報

• CRID: 1390282680740792960
• NII論文ID: 130005151853
• DOI: 10.2131/fts.3.109
• ISSN: 2189115X
• Web Site: https://www.jstage.jst.go.jp/article/fts/3/3/3_109/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2017384101
• 本文言語コード: en
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