Utility of Cystatin C for Estimating Glomerular Filtration Rate in Patients With Muscular Dystrophy:A Good Agreement With Inulin Clearance

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Author(s)

    • Kimura Koichi
    • Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
    • Nagata Tetsuya
    • Department of Molecular Therapy, National Center of Neurology and Psychiatry
    • Takeda Shin'ichi
    • Department of Molecular Therapy, National Center of Neurology and Psychiatry
    • Komaki Hirofumi
    • Department of Child Neurology, National Center of Neurology and Psychiatry
    • Segawa Kazuhiko
    • Department of Cardiology, National Center of Neurology and Psychiatry
    • Komuro Issei
    • Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
    • Morita Hiroyuki
    • Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
    • Daimon Masao
    • Department of Clinical Laboratory Medicine, Graduate School of Medicine, The University of Tokyo
    • Horio Masaru
    • Department of Functional Diagnostic Science, Graduate School of Medicine, Osaka University
    • Kawata Takayuki
    • Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
    • Nakao Tomoko
    • Department of Clinical Laboratory Medicine, Graduate School of Medicine, The University of Tokyo
    • Hirokawa Megumi
    • Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo

Abstract

Emerging concerns regarding heart failure, arrhythmia, and sudden death in patients with muscular dystrophy are of significant clinical importance. On the other hand, little attention has been paid to renal dysfunction because these patients have low serum creatinine levels. Serum cystatin C, unaffected by muscle quantity, is a potentially superior marker for estimating renal function. Here, we present cases with muscular dystrophy in which estimated glomerular filtration rate (GFR) by cystatin C (eGFRcys) provided good agreement with simultaneously measured GFR by inulin renal clearance (differences less than 20%). Sudden death with acute heart failure occurred in a patient with underlying renal dysfunction and elevated BNP. Neurologists and cardiologists should evaluate renal function using GFR with cystatin C in patients with muscular dystrophy.

Journal

  • International Heart Journal

    International Heart Journal 57(3), 386-388, 2016

    International Heart Journal Association

Codes

  • NII Article ID (NAID)
    130005153700
  • Text Lang
    ENG
  • ISSN
    1349-2365
  • Data Source
    J-STAGE 
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