Modification of Cell-Substrate Interface Using TiO<sub>2</sub> Photocatalysis

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  • 光触媒作用を用いた液中表面改質による培養神経細胞の操作
  • ヒカリ ショクバイ サヨウ オ モチイタ エキ ナカオモテメン カイシツ ニ ヨル バイヨウ シンケイ サイボウ ノ ソウサ

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Abstract

Dissociated neurons form a uniform network in culture that covers the whole coverslip. The number of neurons in the network and extent of their axon/dendrite elaboration can be controlled by using micropatterned surfaces as growth scaffolds. “Defined” neuronal networks thus fabricated make it possible to study how structure of a network correlates with its functional properties. We first describe surface micropatterning techniques can be used to make an array of neurons and to direct axon-dendrite polarity of each cell. To create functional networks, the isolated neurons must subsequently be interconnected. To accomplish this, the cell-repellent domain between individual neurons needs to be altered from cell-repellent to cell-permissive in the culture medium, so that the neurons would be hard-wired. We developed for this purpose a novel surface modification method using titanium dioxide photocatalysis.

Journal

  • Hyomen Kagaku

    Hyomen Kagaku 37 (5), 224-229, 2016

    The Surface Science Society of Japan

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