DNA—ポリエチレングリコール—脂質複合体を用いた細胞表面修飾 Cell Surface Engineering Using DNA-poly(ethylene glycol)-lipid Conjugates

この論文にアクセスする

この論文をさがす

著者

抄録

Engineering of cell surface with natural and synthetic molecules is expected to provide new approaches for biomedical applications. We have used single-stranded DNA (ssDNA), which was conjugated both to poly (ethylene glycol) and to a terminal phospholipid for cell surface engineering. The lipid moiety is inserted in the lipid bilayer of living cells through hydrophobic interaction, resulting in presentation of ssDNA on the cells surface. This allows for modification of cell surface with biomolecules and attachment of cells to either substrates or different cells, all of which present the complementary ssDNA. The modification of cell surface with proteins or drug-loaded liposomes effectively suppress undesirable biological reactions on cell surface. In addition, high specificity of DNA hybridization and variation of DNA sequences enable to control cell-substrate and cell-cell attachment in a spatially controlled manner. This technique is useful to biomedical applications including cell therapy and tissue engineering.

収録刊行物

  • 表面科学

    表面科学 37(5), 218-223, 2016

    公益社団法人 日本表面科学会

各種コード

  • NII論文ID(NAID)
    130005154322
  • NII書誌ID(NCID)
    AN00334149
  • 本文言語コード
    JPN
  • ISSN
    0388-5321
  • NDL 記事登録ID
    027337481
  • NDL 請求記号
    Z15-379
  • データ提供元
    NDL  J-STAGE 
ページトップへ