Positive Association of Plasma Homocysteine Levels with Cardio-Ankle Vascular Index in a Prospective Study of Japanese Men from the General Population

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Author(s)

    • Mantjoro Eva Mariane
    • Department of International Islands and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences|Faculty of Public Health, Sam Ratulangi University
    • Kairupan Tara Sefanya
    • Department of International Islands and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences|Faculty of Medicine, Sam Ratulangi University
    • Nindita Yora
    • Department of International Islands and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences|Department of Pharmacology and Therapeutic, Faculty of Medicine, Diponegoro University
    • Ibusuki Rie
    • Department of International Islands and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences
    • Nerome Yasuhito
    • Education Center for Doctors in Remote Islands and Rural Areas, Kagoshima University Graduate School of Medical and Dental Sciences
    • Owaki Tetsuhiro
    • Education Center for Doctors in Remote Islands and Rural Areas, Kagoshima University Graduate School of Medical and Dental Sciences
    • Takezaki Toshiro
    • Department of International Islands and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences
    • Toyota Kousuke
    • Laboratory of Veterinary Pathobiology, Department of Veterinary Medicine, Joint Faculty of Veterinary Medicine, Kagoshima University
    • Kanouchi Hiroaki
    • Laboratory of Veterinary Pathobiology, Department of Veterinary Medicine, Joint Faculty of Veterinary Medicine, Kagoshima University
    • Kuwabara Kazuyo
    • Department of Preventive Medicine and Public Health, School of Medicine, Keio University
    • Nakahata Noriko
    • Department of International Islands and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences|Department of Community Medicine Management, Faculty of Medicine, Shimane University
    • Ogawa Shin
    • Department of International Islands and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences|National Health Insurance Yamato Clinic
    • Shimatani Keiichi
    • Department of International Islands and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences

Abstract

<b><i>Aim</i></b><b>: </b>Observational studies have reported that elevated homocysteine (Hcy) levels are associated with the risk of cardiovascular disease (CVD). However, interventions that lower Hcy do not provide a corresponding risk reduction. Therefore, the causal role of Hcy in CVD remains unclear. This 5-year prospective study investigated the associations of Hcy levels, folate intake, and host factors with arterial stiffness among the general Japanese population.<br><b><i>Methods</i></b><b>: </b>We prospectively recruited 658 participants (40–69 years old) from the general population during regular health checkup examinations. Arterial stiffness was evaluated using the cardio-ankle vascular index (CAVI) at baseline and the 5-year follow-up. Folate intake was estimated using a structured questionnaire. Genotyping was used to evaluate the <i>MTHFR</i> C677T and <i>MS</i> A2756G gene polymorphisms. Ultrafast liquid chromatography was used to measure total plasma Hcy levels. Association between these variables and CAVI values was evaluated using general linear regression and logistic regression models that were adjusted for atherosclerosis-related factors.<br><b><i>Results</i></b><b>: </b>Men had higher Hcy levels and CAVI values and lower folate intake than women (all, <i>p</i><0.001). At baseline, Hcy, folate intake, and the two genotypes were not associated with CAVI values for both sexes. Among men, Hcy levels were positively associated with CAVI values at the 5-year follow-up (<i>p</i>=0.033). Folate intake and the two genotypes were not associated with the 5-year CAVI values.<br><b><i>Conclusion</i></b><b>: </b>Plasma Hcy may be involved in arterial stiffness progression, as monitored using CAVI, among men.

Journal

  • Journal of Atherosclerosis and Thrombosis

    Journal of Atherosclerosis and Thrombosis 23(6), 681-691, 2016

    Japan Atherosclerosis Society

Codes

  • NII Article ID (NAID)
    130005154755
  • Text Lang
    ENG
  • ISSN
    1340-3478
  • Data Source
    J-STAGE 
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