Bone augmentation around a dental implant using demineralized bone sheet containing biologically active substances

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Author(s)

    • SHIRAI Mai
    • Department of Removable Prosthodontics, Tsurumi University School of Dental Medicine
    • YAMAMOTO Ryuji
    • Department of Biochemistry and Molecular Biology, Tsurumi University School of Dental Medicine
    • CHIBA Toshie
    • Department of Oral Anatomy, Tsurumi University School of Dental Medicine
    • KOMATSU Koichiro
    • Department of Pharmacology, Tsurumi University School of Dental Medicine
    • SHIMODA Shinji
    • Department of Oral Anatomy, Tsurumi University School of Dental Medicine
    • YAMAKOSHI Yasuo
    • Department of Biochemistry and Molecular Biology, Tsurumi University School of Dental Medicine
    • OIDA Shinichiro
    • Department of Biochemistry and Molecular Biology, Tsurumi University School of Dental Medicine
    • OHKUBO Chikahiro
    • Department of Removable Prosthodontics, Tsurumi University School of Dental Medicine

Abstract

This study was designed to evaluate the volume of alveolar bone augmentation after immediate implant placement using demineralized bone. We examined the collagen matrix of demineralized bone and biologically active substances contained therein. Rat maxillary first molars were extracted, and the animals were divided into five groups as follows: tooth extraction only, implant into the mesial root socket, implant and other root sockets covered with demineralized bone sheet, implant and other root sockets filled with demineralized bone powder under the sheet, and implant and other root sockets covered with demineralized bone sheet from which proteins were extracted. We ascertained whether biologically active substances are contained in extracted proteins. Biologically active substances were detected in extracted proteins. Conditions using demineralized bone sheet with biologically active substances significantly augmented the height of the alveolar bone. Such resorbable membranes containing biologically active substances hold promise as clinical agents for bone augmentation upon implantation.

Journal

  • Dental Materials Journal

    Dental Materials Journal 35(3), 470-478, 2016

    The Japanese Society for Dental Materials and Devices

Codes

  • NII Article ID (NAID)
    130005155180
  • Text Lang
    ENG
  • ISSN
    0287-4547
  • Data Source
    J-STAGE 
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