Clinicopathological significance of lymphangiogenesis detected by immunohistochemistry using D2-40 monoclonal antibody in breast cancer

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Author(s)

    • Abe Noriko
    • Department of Organ Regulatory Surgery, Fukushima Medical University
    • Ohtake Tohru
    • Department of Organ Regulatory Surgery, Fukushima Medical University
    • Saito Katsuharu
    • Department of Organ Regulatory Surgery, Fukushima Medical University
    • Sugino Takashi
    • Division of Diagnostic Pathology, Shizuoka Cancer Center Hospital

Abstract

To elucidate the association between the lymphangiogenesis and clinicopathological factors including the survival in breast cancer, 91 Japanese patients with breast cancer were investigated. The lymphangiogenesis was evaluated by the count of lymph vessel density (LVD) with immunohistochemical method using D2-40 monoclonal antibody, a specific marker for lymphatic endothelial cells.<br>D2-40-positive lymph vessels were detected in 87 of 91 cases, and were mainly distributed in the peritumoral lesions or around the tumor edge. There was a significant difference in disease-free survival (DFS) and overall survival (OS) between patients with high LVD and with low LVD (<i>p</i>=0.02, 0.01, respectively, log-rank test). In addition, LVD significantly correlated with the following clinicopathological factors: menopausal status (<i>p</i><0.01), tumor size (<i>p</i><0.01), lymph-node status (<i>p</i>=0.01) lymphatic vessel invasion (LVI) (<i>p</i><0.01), blood vessel invasion (BVI) (<i>p</i>=0.03) and estrogen receptor status (ER) (<i>p</i>=0.02).<br>Those data suggest that D2-40 monoclonal antibody is a useful marker for evaluating the LVD and its evaluation is helpful to predict the survival in breast cancer.

Journal

  • FUKUSHIMA JOURNAL OF MEDICAL SCIENCE

    FUKUSHIMA JOURNAL OF MEDICAL SCIENCE 62(1), 57-63, 2016

    The Fukushima Society of Medical Science

Codes

  • NII Article ID (NAID)
    130005156337
  • NII NACSIS-CAT ID (NCID)
    AA0065246X
  • Text Lang
    ENG
  • Article Type
    journal article
  • ISSN
    0016-2590
  • Data Source
    IR  J-STAGE 
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