The roles of bile acid signaling and its interactions with a lipid mediator
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- Nagahashi Masayuki
- Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences
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- Ohashi Taku
- Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences
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- Takizawa Kazuyasu
- Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences
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- Sakata Jun
- Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences
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- Kobayashi Takashi
- Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences
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- Wakai Toshifumi
- Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences
Bibliographic Information
- Other Title
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- 脂質メディエーターを介した胆汁酸シグナル伝達系の役割
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Abstract
Recent advances in molecular biology have revealed existence of specific receptors for bile acids, and the roles of bile acids as signaling molecules have attracted increasing attention. It has been revealed that conjugated bile acids specifically activate sphingosine-1-phosphate (S1P) receptor type 2 (S1PR2). The activation of S1PR2 by conjugated bile acids stimulates SphK2, one of two sphingosine kinases which produces S1P. It has been reported that conjugated bile acids and S1P signaling via S1PR2 and SphK2 regulate lipid and glucose metabolism in the liver, and promote progression of cholangiocellular carcinoma. These findings suggest that bile acids and S1P signaling associate with variety of pathophysiology. Here, we introduce the roles of bile acid signaling and its interactions with S1P signaling via S1PR2 and SphK2 in the pathophysiology of hepatobiliary diseases.
Journal
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- Tando
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Tando 30 (2), 220-227, 2016
Japan Biliary Association
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Keywords
Details 詳細情報について
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- CRID
- 1390282679324599552
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- NII Article ID
- 130005157398
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- ISSN
- 18836879
- 09140077
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- Text Lang
- ja
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- Data Source
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- JaLC
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed