Methotrexate-associated Intravascular Large B-cell Lymphoma in a Patient with Rheumatoid Arthritis
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- Kikuchi Jun
- Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Japan
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- Kaneko Yuko
- Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Japan
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- Kasahara Hidenori
- Division of Hematology, Department of Internal Medicine, Keio University School of Medicine, Japan
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- Emoto Katsura
- Division of Diagnostic Pathology, Keio University Hospital, Japan
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- Kubo Akiharu
- Department of Dermatology, Keio University School of Medicine, Japan
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- Okamoto Shinichiro
- Division of Hematology, Department of Internal Medicine, Keio University School of Medicine, Japan
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- Takeuchi Tsutomu
- Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Japan
Abstract
Intravascular large B-cell lymphoma (IVLBCL) is a rare and clinically aggressive lymphoma with an unfavorable prognosis. We report the case of a 50-year-old woman who was diagnosed with IVLBCL during treatment with methotrexate (MTX) and biologic agents for rheumatoid arthritis. The symptoms showed partial improvement only after the cessation of both treatments. She subsequently received chemotherapy and achieved a complete remission and has remained free of recurrence for 2 years without any further treatment. We herein describe a rare case of IVLBCL which presented with the features of an MTX-associated lymphoproliferative disorder.
Journal
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- Internal Medicine
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Internal Medicine 55 (12), 1661-1665, 2016
The Japanese Society of Internal Medicine
