Histopathological Features of Brain Arteriovenous Malformations in Japanese Patients

• HERMANTO Yulius

  Department of Neurosurgery, Kyoto University Graduate School of Medicine

• TAKAGI Yasushi

  Department of Neurosurgery, Kyoto University Graduate School of Medicine

• YOSHIDA Kazumichi

  Department of Neurosurgery, Kyoto University Graduate School of Medicine

• ISHII Akira

  Department of Neurosurgery, Kyoto University Graduate School of Medicine

• KIKUCHI Takayuki

  Department of Neurosurgery, Kyoto University Graduate School of Medicine

• FUNAKI Takeshi

  Department of Neurosurgery, Kyoto University Graduate School of Medicine

• MINEHARU Yohei

  Department of Neurosurgery, Kyoto University Graduate School of Medicine

• MIYAMOTO Susumu

  Department of Neurosurgery, Kyoto University Graduate School of Medicine

Abstract

Clinical features of high risk brain arteriovenous malformations (BAVMs) are well characterized. However, pathological evidences about the differences that are possessed by high risk patients are still lacking. We reviewed archived routine hematoxylin-eosin specimens from a total of 54 surgical treated BAVMs. The histopathological features in nidus were semi-quantitatively analyzed. We obtained the pathological differences of BAVMs nidus between several clinical features. Among the analyzed pathological features, the significant differences were observed in degree of venous enlargement and intimal hyperplasia. Juvenile, female, diffuse nidus, high Spetzler-Martin grade, and low flow patients had a lesser degree of those parameters compared to adult, male, compact nidus, low Spetzler-Martin grade and high flow patients. High risk profiles of BAVMs patients were well-reflected in the nidus pathology. Therefore, juvenile, female, diffuse nidus, and low flow in Japanese BAVMs patients might have different vascular remodeling process that predispose to higher tendency of hemorrhage.

Journal

• Neurologia medico-chirurgica

  Neurologia medico-chirurgica 56 (6), 340-344, 2016

  The Japan Neurosurgical Society

Keywords

• arteriovenous malformations
• histopathological study
• clinical features
• nidus

Details

• CRID: 1390001205056218368
• NII Article ID: 130005157730
• NII Article ID: 120006335655
• DOI: 10.2176/nmc.oa.2016-0032
• ISSN: 13498029
• ISSN: 04708105
• HANDLE: 2433/226827
• PubMed: 27053330
• Web Site: https://www.jstage.jst.go.jp/article/nmc/56/6/56_oa.2016-0032/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2016337915
• Text Lang: en
• Data Source:
  • JaLC
  • IRDB
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed