Vitamin D Deficiency with High Intact PTH Levels is More Common in Younger than in Older Women: A Study of Women Aged 39–64 Years
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- Miyamoto Takeshi
- Department of Orthopedic Surgery, Keio University School of Medicine, Tokyo, Japan
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- Katsuyama Eri
- Department of Orthopedic Surgery, Keio University School of Medicine, Tokyo, Japan
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- Kanagawa Hiroya
- Department of Orthopedic Surgery, Keio University School of Medicine, Tokyo, Japan
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- Fujie Atsuhiro
- Department of Orthopedic Surgery, Keio University School of Medicine, Tokyo, Japan
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- Miyamoto Hiroya
- Department of Orthopedic Surgery, Keio University School of Medicine, Tokyo, Japan
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- Yoshida Shigeyuki
- Department of Dentistry and Oral Surgery, Keio University School of Medicine, Tokyo, Japan
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- Mori Tomoaki
- Department of Orthopedic Surgery, Keio University School of Medicine, Tokyo, Japan
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- Miyamoto Kana
- Department of Orthopedic Surgery, Keio University School of Medicine, Tokyo, Japan
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- Sato Yuiko
- Department of Orthopedic Surgery, Keio University School of Medicine, Tokyo, Japan
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- Kobayashi Tami
- Department of Orthopedic Surgery, Keio University School of Medicine, Tokyo, Japan
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- Nakamura Masaya
- Department of Orthopedic Surgery, Keio University School of Medicine, Tokyo, Japan
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- Matsumoto Morio
- Department of Orthopedic Surgery, Keio University School of Medicine, Tokyo, Japan
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- Nishiwaki Yuji
- Department of Environmental and Occupational Health, School of Medicine, Toho University, Tokyo, Japan
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- Hirose Hiroshi
- Health Center and Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
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- Kanda Takeshi
- Health Center and Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
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- Saito Ikuo
- Health Center and Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
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- Toyama Yoshiaki
- Department of Orthopedic Surgery, Keio University School of Medicine, Tokyo, Japan
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Abstract
Low serum 25-hydroxyvitamin D (25(OH)D) levels are implicated as a risk factor for hip and spine fractures. Studies of the relation between 25(OH)D levels and fractures have primarily involved elderly osteoporosis patients or patients with fractures; however, the serum 25(OH)D and parathyroid hormone (PTH) status in younger adult populations remains largely unknown. We evaluated serum 25(OH)D and intact PTH levels in 411 women aged 39–64 years who were not receiving medication for osteoporosis or other bone diseases. Serum 25(OH)D levels were positively correlated with age (P = 0.019), whereas intact PTH levels were inversely correlated with 25(OH)D levels (P < 0.001). Thus, low vitamin D levels with high intact PTH levels were more common in younger than in older women. Our data show that serum 25(OH)D insufficiency could be a more serious concern in the younger population than had been previously anticipated. Because serum 25(OH)D insufficiency is reportedly a risk factor for hip and spine fracture, the number of fracture patients could increase in the future, suggesting that we may need to correct the serum vitamin D/intact PTH status to prevent future osteoporosis.
Journal
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- The Keio Journal of Medicine
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The Keio Journal of Medicine 65 (2), 33-38, 2016
The Keio Journal of Medicine