8-Quinolinol誘導体の化学反応とバイオケミカルツール·酵素阻害剤への応用

DOI Web Site Web Site 被引用文献2件 参考文献105件

書誌事項

タイトル別名
  • Chemical Reactions of 8-Quinolinol Derivatives and Their Applications to Biochemical Tools and Enzyme Inhibitors
  • 8-Quinolinol誘導体の化学反応とバイオケミカルツール・酵素阻害剤への応用
  • 8-Quinolinol ユウドウタイ ノ カガク ハンノウ ト バイオケミカルツール ・ コウソ ソガイザイ エ ノ オウヨウ

この論文をさがす

抄録

8-Quinolinol (8-hydroxyquioline, 8HQ) attracts much attention in material sciences and bio-related sciences, because of their simple structures, strong metal coordination properties, fluorescence properties, and extensive possibility of functionalization. In this review, five applications of 8HQ are described. The first application is 8HQ-linked macrocyclic tetraamines as fluorescent probes of zinc ions in living cell. The second and third sections provide the applications of 8HQ to inhibitors against dinuclear zinc hydrolase and to radioprotectors that can inhibit apoptosis of radiosensitive normal cells during radiotherapy. In the third section, finding of photochemical S-O bond cleavage reaction of 8HQ sulfonates (8HQS) under aqueous conditions, its mechanistic analysis and applications to photocleavable chemical linkers are described. Finally, the photophysical properties of iridium(III) complexes having 8HQ or its analogs will be presented. This knowledge will be useful in design and synthesis of useful molecules containing 8HQ units, in bioorganic chemistry, chemical biology, pharmaceutical science, material science, and other related scientific fields.

収録刊行物

被引用文献 (2)*注記

もっと見る

参考文献 (105)*注記

もっと見る

関連プロジェクト

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ