Bacteriophage can lyse antibiotic-resistant Pseudomonas aeruginosa isolated from canine diseases Bacteriophage can lyse antibiotic-resistant <i>Pseudomonas aeruginosa</i> isolated from canine diseases

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Author(s)

    • FURUSAWA Takaaki FURUSAWA Takaaki
    • Laboratory of Veterinary Biochemistry, School of Veterinary Medicine, Rakuno Gakuen University, 582 Bunkyodai-Midorimachi Ebetsu, Hokkaido 069–8501, Japan
    • IWANO Hidetomo IWANO Hidetomo
    • Laboratory of Veterinary Biochemistry, School of Veterinary Medicine, Rakuno Gakuen University, 582 Bunkyodai-Midorimachi Ebetsu, Hokkaido 069–8501, Japan
    • HIGUCHI Hidetoshi HIGUCHI Hidetoshi
    • Laboratory of Veterinary Hygiene, School of Veterinary Medicine, Rakuno Gakuen University, 582 Bunkyodai-Midorimachi Ebetsu, Hokkaido 069–8501, Japan
    • YOKOTA Hiroshi YOKOTA Hiroshi
    • Laboratory of Veterinary Biochemistry, School of Veterinary Medicine, Rakuno Gakuen University, 582 Bunkyodai-Midorimachi Ebetsu, Hokkaido 069–8501, Japan
    • USUI Masaru USUI Masaru
    • Laboratory of Food Microbiology and Food Safety, School of Veterinary Medicine, Rakuno Gakuen University, 582 Bunkyodai-Midorimachi Ebetsu, Hokkaido 069–8501, Japan
    • IWASAKI Tomohito IWASAKI Tomohito
    • Laboratory of Applied Biochemistry, Department of Food Science and Human Wellness, Rakuno Gakuen University, Ebetsu, Hokkaido 069–8501, Japan
    • TAMURA Yutaka TAMURA Yutaka
    • Laboratory of Food Microbiology and Food Safety, School of Veterinary Medicine, Rakuno Gakuen University, 582 Bunkyodai-Midorimachi Ebetsu, Hokkaido 069–8501, Japan

Abstract

<i>Pseudomonas aeruginosa</i> is a pathogen frequently identified as the cause of diverse infections or chronic disease. This microbe has natural resistance to several kinds of antibiotics, because of the species' outer membrane, efflux pumps and growth as a biofilm. This bacterium can acquire increased resistance with specific point mutations. Bacteriophage (phage), however, can lyse these bacteria. Therefore, in the present study, we assessed the host range of phages isolates and their ability to lyse antibiotic-resistant <i>P. aeruginosa</i>. Present phages could lyse many strains of <i>P. aeruginosa</i> (28/39), including strains with high resistance to fluoroquinolones (4/6). In conclusion, application of phages for antibiotic-resistant bacteria is greatly effective. To avoid pervasive antibiotic-resistant bacteria, further development of phage usage for disease treatment is required.

Journal

  • Journal of Veterinary Medical Science

    Journal of Veterinary Medical Science 78(6), 1035-1038, 2016

    JAPANESE SOCIETY OF VETERINARY SCIENCE

Codes

  • NII Article ID (NAID)
    130005159671
  • NII NACSIS-CAT ID (NCID)
    AA10796138
  • Text Lang
    ENG
  • Article Type
    journal article
  • ISSN
    0916-7250
  • NDL Article ID
    027518955
  • NDL Call No.
    Z18-350
  • Data Source
    NDL  IR  J-STAGE 
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