Bacteriophage can lyse antibiotic-resistant Pseudomonas aeruginosa isolated from canine diseases Bacteriophage can lyse antibiotic-resistant <i>Pseudomonas aeruginosa</i> isolated from canine diseases
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<i>Pseudomonas aeruginosa</i> is a pathogen frequently identified as the cause of diverse infections or chronic disease. This microbe has natural resistance to several kinds of antibiotics, because of the species' outer membrane, efflux pumps and growth as a biofilm. This bacterium can acquire increased resistance with specific point mutations. Bacteriophage (phage), however, can lyse these bacteria. Therefore, in the present study, we assessed the host range of phages isolates and their ability to lyse antibiotic-resistant <i>P. aeruginosa</i>. Present phages could lyse many strains of <i>P. aeruginosa</i> (28/39), including strains with high resistance to fluoroquinolones (4/6). In conclusion, application of phages for antibiotic-resistant bacteria is greatly effective. To avoid pervasive antibiotic-resistant bacteria, further development of phage usage for disease treatment is required.
- Journal of Veterinary Medical Science
Journal of Veterinary Medical Science 78(6), 1035-1038, 2016
JAPANESE SOCIETY OF VETERINARY SCIENCE