Bacteriophage can lyse antibiotic-resistant Pseudomonas aeruginosa isolated from canine diseases Bacteriophage can lyse antibiotic-resistant <i>Pseudomonas aeruginosa</i> isolated from canine diseases

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著者

    • FURUSAWA Takaaki FURUSAWA Takaaki
    • Laboratory of Veterinary Biochemistry, School of Veterinary Medicine, Rakuno Gakuen University, 582 Bunkyodai-Midorimachi Ebetsu, Hokkaido 069–8501, Japan
    • IWANO Hidetomo IWANO Hidetomo
    • Laboratory of Veterinary Biochemistry, School of Veterinary Medicine, Rakuno Gakuen University, 582 Bunkyodai-Midorimachi Ebetsu, Hokkaido 069–8501, Japan
    • HIGUCHI Hidetoshi HIGUCHI Hidetoshi
    • Laboratory of Veterinary Hygiene, School of Veterinary Medicine, Rakuno Gakuen University, 582 Bunkyodai-Midorimachi Ebetsu, Hokkaido 069–8501, Japan
    • YOKOTA Hiroshi YOKOTA Hiroshi
    • Laboratory of Veterinary Biochemistry, School of Veterinary Medicine, Rakuno Gakuen University, 582 Bunkyodai-Midorimachi Ebetsu, Hokkaido 069–8501, Japan
    • USUI Masaru USUI Masaru
    • Laboratory of Food Microbiology and Food Safety, School of Veterinary Medicine, Rakuno Gakuen University, 582 Bunkyodai-Midorimachi Ebetsu, Hokkaido 069–8501, Japan
    • IWASAKI Tomohito IWASAKI Tomohito
    • Laboratory of Applied Biochemistry, Department of Food Science and Human Wellness, Rakuno Gakuen University, Ebetsu, Hokkaido 069–8501, Japan
    • TAMURA Yutaka TAMURA Yutaka
    • Laboratory of Food Microbiology and Food Safety, School of Veterinary Medicine, Rakuno Gakuen University, 582 Bunkyodai-Midorimachi Ebetsu, Hokkaido 069–8501, Japan

抄録

<i>Pseudomonas aeruginosa</i> is a pathogen frequently identified as the cause of diverse infections or chronic disease. This microbe has natural resistance to several kinds of antibiotics, because of the species' outer membrane, efflux pumps and growth as a biofilm. This bacterium can acquire increased resistance with specific point mutations. Bacteriophage (phage), however, can lyse these bacteria. Therefore, in the present study, we assessed the host range of phages isolates and their ability to lyse antibiotic-resistant <i>P. aeruginosa</i>. Present phages could lyse many strains of <i>P. aeruginosa</i> (28/39), including strains with high resistance to fluoroquinolones (4/6). In conclusion, application of phages for antibiotic-resistant bacteria is greatly effective. To avoid pervasive antibiotic-resistant bacteria, further development of phage usage for disease treatment is required.

収録刊行物

  • The Journal of Veterinary Medical Science

    The Journal of Veterinary Medical Science 78(6), 1035-1038, 2016

    日本獣医学会

各種コード

  • NII論文ID(NAID)
    130005159671
  • NII書誌ID(NCID)
    AA10796138
  • 本文言語コード
    ENG
  • 資料種別
    journal article
  • ISSN
    0916-7250
  • NDL 記事登録ID
    027518955
  • NDL 請求記号
    Z18-350
  • データ提供元
    NDL  IR  J-STAGE 
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