Gold-Catalyzed Cyclization of Alkyne Alcohols: Regioselective Construction of Functionalized 6,6- and 6,7-Bicyclic Ethers
-
- Kubota Mio
- Graduate School of Pharmaceutical Sciences, The University of Tokyo
-
- Saito Tatsuo
- Graduate School of Pharmaceutical Sciences, The University of Tokyo
-
- Miyamoto Kazunori
- Graduate School of Pharmaceutical Sciences, The University of Tokyo
-
- Hirano Keiichi
- Graduate School of Pharmaceutical Sciences, The University of Tokyo
-
- Wang Chao
- Graduate School of Pharmaceutical Sciences, The University of Tokyo Advanced Elements Chemistry Research Team, RIKEN Center for Sustainable Resource Science, and Elements Chemistry Laboratory, RIKEN
-
- Uchiyama Masanobu
- Graduate School of Pharmaceutical Sciences, The University of Tokyo Advanced Elements Chemistry Research Team, RIKEN Center for Sustainable Resource Science, and Elements Chemistry Laboratory, RIKEN
Search this article
Abstract
We describe an efficient regioselective formation of six-/seven-membered cyclic ethers based on gold-catalyzed intramolecular hydroalkoxylation. Sequential gold-catalyzed cyclization and palladium-catalyzed cross-coupling reactions afforded 6,6-bicyclic ethers, while reversing the reaction sequence (cross-coupling then cyclization) afforded 6,7-bicyclic ethers. This methodology should provide access to a range of functional polycyclic ethers.
Journal
-
- Chemical and Pharmaceutical Bulletin
-
Chemical and Pharmaceutical Bulletin 64 (7), 845-855, 2016
The Pharmaceutical Society of Japan
- Tweet
Details 詳細情報について
-
- CRID
- 1390001204178790912
-
- NII Article ID
- 130005160029
-
- NII Book ID
- AA00602100
-
- ISSN
- 13475223
- 00092363
-
- NDL BIB ID
- 027451572
-
- PubMed
- 27373641
-
- Text Lang
- en
-
- Data Source
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
-
- Abstract License Flag
- Disallowed