Organocatalytic Site-Selective Acylation of 10-Deacetylbaccatin III

• Yanagi Masanori

  Institute for Chemical Research, Kyoto University

• Ninomiya Ryo

  Institute for Chemical Research, Kyoto University

• Ueda Yoshihiro

  Institute for Chemical Research, Kyoto University

• Furuta Takumi

  Institute for Chemical Research, Kyoto University

• Yamada Takeshi

  Kitasato Institute for Life Sciences, Kitasato University Graduate School of Infection Control Sciences, Kitasato University

• Sunazuka Toshiaki

  Kitasato Institute for Life Sciences, Kitasato University Graduate School of Infection Control Sciences, Kitasato University

• Kawabata Takeo

  Institute for Chemical Research, Kyoto University

抄録

Organocatalytic site-selective diversification of 10-deacetylbaccatin III, a key natural product for the semisynthesis of taxol, has been achieved. Various acyl groups were selectively introduced into the C(10)–OH of 10-deacetylbaccatin III. The C(10)–OH selective acylation was also applied to acylative site-selective dimerization of 10-deacetylbaccatin III to provide the structurally defined dimer.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 64 (7), 907-912, 2016

  公益社団法人 日本薬学会

キーワード

• organocatalyst
• site-selectivity
• acylation
• taxane
• 10-deacetylbaccatin III
• site-selective dimerization

詳細情報

• CRID: 1390282679154114816
• NII論文ID: 130005160042
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.c16-00037
• ISSN: 13475223
• ISSN: 00092363
• NDL書誌ID: 027451678
• PubMed: 26903156
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I027451678
• Web Site: https://www.jstage.jst.go.jp/article/cpb/64/7/64_c16-00037/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2017038269
• 本文言語コード: en
• データソース種別:
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  • NDL
  • Crossref
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  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可