Novel 3,4,7-Substituted Benzofuran Derivatives Having Binding Affinity to κ-Opioid Receptor

• Nishiyama Daisuke

  Graduate School of Pharmaceutical Sciences, Kyoto University

• Sakai Yuki

  Graduate School of Pharmaceutical Sciences, Kyoto University

• Sekiguchi Haruka

  Graduate School of Pharmaceutical Sciences, Kyoto University

• Chiba Hiroaki

  Graduate School of Pharmaceutical Sciences, Kyoto University

• Misu Ryosuke

  Graduate School of Pharmaceutical Sciences, Kyoto University

• Oishi Shinya

  Graduate School of Pharmaceutical Sciences, Kyoto University

• Fujii Nobutaka

  Graduate School of Pharmaceutical Sciences, Kyoto University

• Ohno Hiroaki

  Graduate School of Pharmaceutical Sciences, Kyoto University

抄録

A series of novel 3,4,7-trisubstituted benzofuran derivatives were synthesized, and their binding affinity to κ- (KOR) and μ-opioid receptors (MOR) were evaluated. Several aryl ethers showed moderate binding activities to KOR (IC₅₀=3.9–11 µM) without binding to MOR.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 64 (7), 996-1003, 2016

  公益社団法人 日本薬学会

キーワード

• κ-opioid receptor
• opioid
• benzofuran
• morphine

詳細情報

• CRID: 1390001204178874112
• NII論文ID: 130005160050
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.c16-00302
• ISSN: 13475223
• ISSN: 00092363
• NDL書誌ID: 027451877
• PubMed: 27373662
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I027451877
• Web Site: https://www.jstage.jst.go.jp/article/cpb/64/7/64_c16-00302/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2017038281
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可