<i>N</i>-Methylniphatyne A, a New 3-Alkylpyridine Alkaloid as an Inhibitor of the Cancer Cells Adapted to Nutrient Starvation, from an Indonesian Marine Sponge of <i>Xestospongia</i> sp.

• Arai Masayoshi

  Graduate School of Pharmaceutical Sciences, Osaka University

• Kamiya Kentaro

  Graduate School of Pharmaceutical Sciences, Osaka University

• Shin Dayoung

  Graduate School of Pharmaceutical Sciences, Osaka University

• Matsumoto Hirokazu

  Graduate School of Pharmaceutical Sciences, Osaka University

• Hisa Tomoya

  Graduate School of Pharmaceutical Sciences, Osaka University

• Setiawan Andi

  Department of Chemistry, Faculty of Science, Lampung University

• Kotoku Naoyuki

  Graduate School of Pharmaceutical Sciences, Osaka University

• Kobayashi Motomasa

  Graduate School of Pharmaceutical Sciences, Osaka University

Bibliographic Information

Other Title

• N-Methylniphatyne A, a New 3-Alkylpyridine Alkaloid as an Inhibitor of the Cancer Cells Adapted to Nutrient Starvation, from an Indonesian Marine Sponge of Xestospongia sp

Abstract

In the course of searching for selective growth inhibitors of the cancer cells adapted to nutrient starvation, a new 3-alkylpyridine alkaloid named N-methylniphatyne A (1) was isolated from an Indonesian marine sponge of Xestospongia sp. The chemical structure of 1 was determined on the basis of the spectroscopic analysis and comparison with the synthesized 1 and its analogues. Compound 1 showed the cytotoxic activity against PANC-1 cells under the condition of glucose starvation with IC₅₀ value of 16 µM, whereas no growth-inhibition was observed up to 100 µM under the general culture conditions.

Journal

• Chemical and Pharmaceutical Bulletin

  Chemical and Pharmaceutical Bulletin 64 (7), 766-771, 2016

  The Pharmaceutical Society of Japan

Keywords

• <i>N</i>-methylniphatyne A
• marine sponge
• cancer
• nutrient starvation

Details

• CRID: 1390282679155763328
• NII Article ID: 130005160059
• NII Book ID: AA00602100
• DOI: 10.1248/cpb.c16-00118
• ISSN: 13475223
• ISSN: 00092363
• NDL BIB ID: 027451463
• PubMed: 27373630
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I027451463
• Web Site: https://www.jstage.jst.go.jp/article/cpb/64/7/64_c16-00118/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2017038257
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed