Iriomoteolides-10a and 12a, Cytotoxic Macrolides from Marine Dinoflagellate <i>Amphidinium</i> Species

• Akakabe Mai

  Science Research Center, Kochi University

• Kumagai Keiko

  Science Research Center, Kochi University

• Tsuda Masayuki

  Science Research Center, Kochi University

• Konishi Yuko

  Science Research Center, Kochi University

• Tominaga Akira

  Graduate School of Kuroshio Science and Kochi Medical School, Kochi University

• Kaneno Daisuke

  Research Faculty of Agriculture, Hokkaido University

• Fukushi Eri

  Faculty of Science, Kochi University

• Kawabata Jun

  Faculty of Science, Kochi University

• Masuda Atsunori

  Yanmar Environmental Sustainability Support Association

• Tsuda Masashi

  Center for Advanced Marine Core Research, Kochi University

Bibliographic Information

Other Title

• Iriomoteolides-10a and 12a, Cytotoxic Macrolides from Marine Dinoflagellate Amphidinium Species

Abstract

Two new macrolides, iriomoteolides-10a (1) and -12a (2), have been isolated from a marine dinoflagellate Amphidinium sp. (KCA09053 strain), and their structures were elucidated on the basis of a detailed two dimensional (2D)-NMR analysis. Compound 1 is a novel 21-membered Amphidinium macrolide, which contains one tetrahydrofuran ring, two ketone carbonyls, two hydroxyl groups, and six one-carbon branches. Compound 2 is a new 12-membered macrolide related to amphidinolide Q. Compound 1 exhibited cytotoxic activity against human cervix adenocarcinoma HeLa and murine hepatocellular carcinoma MH134 cells.

Journal

• Chemical and Pharmaceutical Bulletin

  Chemical and Pharmaceutical Bulletin 64 (7), 1019-1023, 2016

  The Pharmaceutical Society of Japan

Keywords

• macrolide
• dinoflagellate
• <i>Amphidinium</i>
• cytotoxic activity

Details

• CRID: 1390001204179060608
• NII Article ID: 130005160062
• NII Book ID: AA00602100
• DOI: 10.1248/cpb.c16-00026
• ISSN: 13475223
• ISSN: 00092363
• NDL BIB ID: 027451904
• PubMed: 27373665
• Web Site: http://id.ndl.go.jp/bib/027451904
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I027451904
• Web Site: https://www.jstage.jst.go.jp/article/cpb/64/7/64_c16-00026/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2017038284
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed