Enhancement of Automaticity by Mechanical Stretch of the Isolated Guinea Pig Pulmonary Vein Myocardium

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  • Hamaguchi Shogo
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University
  • Hikita Koh
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University
  • Tanaka Yusuke
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University
  • Tsuneoka Yayoi
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Tokyo University of Science
  • Namekata Iyuki
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University
  • Tanaka Hikaru
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University

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The effects of mechanical stretch on the automaticity of the guinea pig isolated pulmonary vein preparations were studied in microelectrode experiments. The application of cumulative mechanical stretch to the preparations resulted in increases in the firing rate of spontaneous electrical activity in the myocardial layer. This effect was significantly inhibited by stretch-activated channel blockers such as gadolinium or streptomycin. These results suggest that acute mechanical stretch enhances the automaticity of the guinea pig pulmonary vein myocardium through the opening of the stretch-activated channels.

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