F-fucoidan from Saccharina japonica is a novel inducer of galectin-9 and exhibits anti-allergic activity

• Tanino Yuka

  Graduate School of Agricultural Science, Kobe University

• Hashimoto Takashi

  Graduate School of Agricultural Science, Kobe University

• Ojima Takao

  Faculty of Fisheries Sciences, Hokkaido University

• Mizuno Masashi

  Graduate School of Agricultural Science, Kobe University

書誌事項

タイトル別名

• F-fucoidan from <i>Saccharina japonica</i> is a novel inducer of galectin-9 and exhibits anti-allergic activity

抄録

Fucoidan is a sulfated polysaccharide from brown sea algae. In the present study, it was demonstrated that oral administration of F-fucoidan from Saccharina japonica possessed anti-allergic effects using the passive cutaneous anaphylaxis reaction, but not by intraperitoneal administration. The inhibitory mechanism was dependent on galectin-9, which belongs to a soluble lectin family that recognizes β-galactoside and prevents IgE binding to mast cells. The anti-allergy properties of F-fucoidan were cancelled by an intravenous dose of anti-galectin-9 antibody or lactose, which bind competitively with galectin-9 before the passive cutaneous anaphylaxis reaction. F-fucoidan increased the expression level of galectin-9 mRNA in intestinal epithelial cells and serum galectin-9 levels. Oral treatment with F-fucoidan suppressed allergic symptoms through the induction of galectin-9. This is the first report that F-fucoidan can induce the secretion of galectin-9.

収録刊行物

• Ｊｏｕｒｎａｌ　ｏｆ　Ｃｌｉｎｉｃａｌ　Ｂｉｏｃｈｅｍｉｓｔｒｙ　ａｎｄ　Ｎｕｔｒｉｔｉｏｎ

  Ｊｏｕｒｎａｌ　ｏｆ　Ｃｌｉｎｉｃａｌ　Ｂｉｏｃｈｅｍｉｓｔｒｙ　ａｎｄ　Ｎｕｔｒｉｔｉｏｎ 59 (1), 25-30, 2016

  一般社団法人　日本酸化ストレス学会

キーワード

• F-fucoidan
• allergy
• galectin-9

詳細情報

• CRID: 1390001204671716480
• NII論文ID: 130005160846
• DOI: 10.3164/jcbn.15-144
• ISSN: 18805086
• ISSN: 09120009
• Web Site: https://www.jstage.jst.go.jp/article/jcbn/59/1/59_15-144/_pdf
• 本文言語コード: en
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