蛍光マルチスペクトルイメージングによる動脈硬化の診断技術

• ホー カサンドラ

• 堀内 俊克

• 谷口 裕亮

• 梅津 新矢

• 萩沢 康介

• 岩屋 啓一

• アズミ アマリナ

• ズルアジズ ナターシャ

• アズヒム アズラン

• 四ノ宮 成祥

• 守本 祐司

書誌事項

タイトル別名

• Fluorescence Multispectral Imaging based Diagnostic System for Atherosclerosis

抄録

Previous research has shown that multispectral imaging is successful in obtaining intrinsic fluorescence data in biological tissue and subsequently a possible method in early detection and quantitative evaluation of atherosclerotic lesions. Using a fluorescence multispectral imaging system composed of a highly sensitive CCD camera and a fast multi-channel spectrometer produces intrinsic fluorescence spectra at lesions sites - allowing for an objective evaluation of the disease. A preliminary study using aortas from rabbit atherosclerotic models (developed via high fat diet administration) indicated that atherosclerotic and normal sites could be clearly discriminated based on differences in fluorescence data. In the current study, samples were taken from coronary arteries of human cadavers and subsequent results from multispectral imaging were correlated to the corresponding pathological findings at atherosclerotic sites in order to distinguish the relationship between the severity of the disease and resulting fluorescence spectra and intensity. As a result, the composition of the arterial wall was successfully analyzed and a new method of diagnosing atherosclerosis was established.

収録刊行物

• 生体医工学

  生体医工学 53 (Supplement), S215_03-S215_03, 2015

  公益社団法人 日本生体医工学会

詳細情報

• CRID: 1390282680242778624
• NII論文ID: 130005163581
• DOI: 10.11239/jsmbe.53.s215_03
• ISSN: 18814379
• ISSN: 1347443X
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可