Biological roles and therapeutic potential of G protein-coupled receptors for free fatty acids and metabolic intermediates

• Suzuki Kenji

  College of Pharmaceutical Sciences, Ritsumeikan University

• Kaneko-Kawano Takako

  College of Pharmaceutical Sciences, Ritsumeikan University

抄録

Several G protein-coupled receptors that transmit signals in response to dietary free fatty acids (FFAs) as well as endogenous metabolites, such as lactate and 3-hydroxybutyrate, have been discovered. These receptors are shown to sense levels of energy substrates or metabolic states of the body, and regulate metabolism and endocrine functions of various organs to maintain energy homeostasis. The receptors for FFAs and hydroxy carboxylic acids (HCAs) appear to be involved in several metabolic disorders including obesity, diabetes and atherosclerosis. In this review, we summarize the functions of FFA and HCA receptors in physiology and pathophysiology, and discuss their implications for the treatment of metabolic diseases.

収録刊行物

• The Journal of Physical Fitness and Sports Medicine

  The Journal of Physical Fitness and Sports Medicine 5 (3), 213-227, 2016

  一般社団法人日本体力医学会

キーワード

• G protein-coupled receptor
• free fatty acid
• ketone body
• obesity
• diabetes

詳細情報

• CRID: 1390282680392342272
• NII論文ID: 130005165311
• NII書誌ID: AA12573156
• DOI: 10.7600/jpfsm.5.213
• ISSN: 21868123
• ISSN: 21868131
• NDL書誌ID: 027506870
• Web Site: http://id.ndl.go.jp/bib/027506870
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I027506870
• Web Site: https://www.jstage.jst.go.jp/article/jpfsm/5/3/5_213/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2017039393
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可