Gastroesophageal dysmotility is associated with the impairment of cough-specific quality of life in patients with cough variant asthma

• Kanemitsu Yoshihiro

  Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University Department of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City University School of Medical Sciences

• Niimi Akio

  Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University Department of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City University School of Medical Sciences

• Matsumoto Hisako

  Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University

• Iwata Toshiyuki

  Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University

• Ito Isao

  Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University

• Oguma Tsuyoshi

  Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University

• Inoue Hideki

  Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University

• Tajiri Tomoko

  Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University

• Nagasaki Tadao

  Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University

• Izuhara Yumi

  Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University

• Petrova Guergana

  Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University

• Birring Surinder S.

  Division of Asthma, Allergy and Lung Biology, King's College London

• Mishima Michiaki

  Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University

抄録

Background: Gastroesophageal reflux disease (GERD) is known as a common comorbidity of asthma and chronic cough. The impact of GERD symptoms on cough-specific quality of life (QoL) in patients with asthmatic cough is poorly understood. The aim of this study is to determine the association of GERD symptoms with cough-specific quality of life in patients with cough variant asthma (CVA) using the Leicester Cough Questionnaire (LCQ). Methods: A total of 172 consecutive patients (121 females) with mean cough duration of 45.1 months (range 2-480 months) completed the Japanese version of the LCQ. The Frequency Scale for the Symp- toms of Gastroesophageal reflux was administered to assess symptoms of acid-reflux and dysmotility. A range of clinical variables that may determine cough-specific QoL (LCQ) were estimated. Results: The mean LCQ scores was 12.9 (SD 3.5), consistent with severe impairment in QoL. Female gender, symptoms of gastroesophageal dysmotility, sensitization to allergens (house dust and Japanese cedar pollen) and the number of sensitized allergens were associated with lower LCQ scores (i.e. impaired cough-specific QoL) in univariate regression analysis. Acid-reflux symptoms, airway hyper- responsiveness, fractional exhaled nitric oxide, and sensitization to molds were unrelated to the LCQ score. After adjustment for gender, symptoms of gastroesophageal dysmotility was the only significant determinant of impaired cough-specific QoL accounting for 23% of the variance. Conclusions: Cough-specific QoL is severely impaired in patients with CVA. Symptoms of gastroesoph- ageal dysmotility are an independent predictor of cough-specific QoL of patients with CVA.

収録刊行物

• Allergology International

  Allergology International 65 (3), 320-326, 2016

  一般社団法人日本アレルギー学会

キーワード

• Chronic cough; Cough variant asthma; Gastroesophageal dysmotility; The Leicester Cough Questionnaire; Quality of life

詳細情報

• CRID: 1390282679609223296
• NII論文ID: 130005165869
• DOI: 10.1016/j.alit.2016.02.014
• ISSN: 14401592
• ISSN: 13238930
• HANDLE: 2433/216497
• Web Site: https://api.elsevier.com/content/article/PII:S1323893016300089?httpAccept=text/xml
• Web Site: https://api.elsevier.com/content/article/PII:S1323893016300089?httpAccept=text/plain
• Web Site: https://search.jamas.or.jp/link/ui/2017189677
• 本文言語コード: en
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