Serum Uric Acid as a Risk Factor for Chronic Kidney Disease in a Japanese Community　– The Hisayama Study –

• Takae Keita

  Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University

• Nagata Masaharu

  Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University

• Hata Jun

  Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University Center for Cohort Studies, Graduate School of Medical Sciences, Kyushu University

• Mukai Naoko

  Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University Center for Cohort Studies, Graduate School of Medical Sciences, Kyushu University

• Hirakawa Yoichiro

  Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University

• Yoshida Daigo

  Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University Center for Cohort Studies, Graduate School of Medical Sciences, Kyushu University

• Kishimoto Hiro

  Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University

• Tsuruya Kazuhiko

  Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University

• Kitazono Takanari

  Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University Center for Cohort Studies, Graduate School of Medical Sciences, Kyushu University

• Kiyohara Yutaka

  Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University Center for Cohort Studies, Graduate School of Medical Sciences, Kyushu University

• Ninomiya Toshiharu

  Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University Center for Cohort Studies, Graduate School of Medical Sciences, Kyushu University

Abstract

Background:Growing evidence suggests that high serum uric acid (SUA) levels are causally related to increased risk of chronic kidney disease (CKD). However, few studies have investigated the influence of elevated SUA levels on the incidence of kidney dysfunction and albuminuria separately in community-based populations. Methods and Results:A total of 2,059 community-dwelling Japanese subjects aged ≥40 years without CKD were followed for 5 years. CKD was defined as kidney dysfunction (estimated glomerular filtration rate <60 ml/min/1.73 m²) or albuminuria (urine albumin-creatinine ratio ≥30 mg/g). The odds ratio (OR) for the development of CKD was estimated according to quartiles of SUA (≤4.0, 4.1–4.9, 5.0–5.8, and ≥5.9 mg/dl). During the follow-up, 396 subjects developed CKD, of whom 125 had kidney dysfunction and 312 had albuminuria. The multivariable-adjusted risk of developing CKD increased with higher SUA levels (OR 1.00 [reference] for ≤4.0, 1.21 [95% confidence interval, 0.84–1.74] for 4.1–4.9, 1.47 [1.01–2.17] for 5.0–5.8, and 2.10 [1.37–3.23] for SUA ≥5.9 mg/dl, respectively). Similarly, there were positive associations between SUA level and the adjusted risk of developing kidney dysfunction (OR 1.00 [reference], 2.30 [1.10–4.82], 2.81 [1.34–5.88], and 3.73 [1.65–8.44]) and albuminuria (1.00 [reference], 1.12 [0.76–1.65], 1.35 [0.90–2.03], and 1.81 [1.14–2.87], respectively). Conclusions:Higher SUA levels were a significant risk factor for the development of both kidney dysfunction and albuminuria in a general Japanese population. (Circ J 2016; 80: 1857–1862)

Journal

• Circulation Journal

  Circulation Journal 80 (8), 1857-1862, 2016

  The Japanese Circulation Society

Keywords

• Albuminuria
• Chronic kidney disease
• Epidemiology
• Kidney dysfunction
• Serum uric acid

Details

• CRID: 1390282680082931328
• NII Article ID: 130005166109
• NII Book ID: AA11591968
• DOI: 10.1253/circj.cj-16-0030
• ISSN: 13474820
• ISSN: 13469843
• NDL BIB ID: 027499893
• PubMed: 27319408
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I027499893
• Web Site: https://www.jstage.jst.go.jp/article/circj/80/8/80_CJ-16-0030/_pdf
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed