The IGF-1/Akt/S6 Signaling Pathway is Age-Dependently Downregulated in the Chicken Breast Muscle
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- Saneyasu Takaoki
- Graduate School of Agricultural Science, Kobe University, Japan
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- Inui Mariko
- Graduate School of Agricultural Science, Kobe University, Japan
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- Kimura Sayaka
- Graduate School of Agricultural Science, Kobe University, Japan
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- Yoshimoto Yu
- Graduate School of Agricultural Science, Kobe University, Japan
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- Tsuchii Nami
- Graduate School of Agricultural Science, Kobe University, Japan
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- Shindo Haruka
- Faculty of Agriculture, Kobe University, Japan
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- Honda Kazuhisa
- Graduate School of Agricultural Science, Kobe University, Japan
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- Kamisoyama Hiroshi
- Graduate School of Agricultural Science, Kobe University, Japan
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Abstract
The skeletal muscle mass is known to be controlled by the balance between protein synthesis and degradation. The fractional rate of protein synthesis has been reported to decrease age-dependently from 1 to 4 weeks of age in the chicken breast muscle (pectoralis major muscle). On the other hand, age-dependent change of the fractional protein degradation rate was reported to be less in the skeletal muscle of chickens. These findings suggest that protein synthesis is age-dependently downregulated in chicken muscle. We herein investigated the age-dependent changes in protein synthesis or proteolysis-related factors in the breast muscle of 7, 14, 28, and 49-day old broiler chickens. IGF-1 mRNA level, phosphorylation rate of Akt, and phospho-S6 content were coordinately decreased in an age-dependent manner, suggesting that IGF-1-stimulated protein synthesis is downregulated with age in chicken breast muscle. In contrast, atrogin-1, one of the proteolysis-related factors, gradually increased with age at mRNA levels. However, plasma Nτ-methylhistidine concentration, an indicator of skeletal muscle proteolysis, did not coordinately change with atrogin-1 mRNA levels. Taken together, our results suggest that the IGF-1/Akt/S6 signaling pathway is age-dependently downregulated in the chicken breast muscle.
Journal
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- The Journal of Poultry Science
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The Journal of Poultry Science 53 (3), 213-219, 2016
Japan Poultry Science Association
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Details 詳細情報について
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- CRID
- 1390001205207117312
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- NII Article ID
- 130005166201
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- NII Book ID
- AA11564513
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- ISSN
- 13490486
- 13467395
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- NDL BIB ID
- 027495112
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed