Menaquinone as a potential target of antibacterial agents
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- Paudel Atmika
- Teikyo University Institute of Medical Mycology
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- Hamamoto Hiroshi
- Teikyo University Institute of Medical Mycology
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- Panthee Suresh
- Teikyo University Institute of Medical Mycology
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- Sekimizu Kazuhisa
- Teikyo University Institute of Medical Mycology Genome Pharmaceuticals Institute Co., Ltd.
抄録
<p>The current trend of increasing infections by multidrug-resistant pathogens requires the discovery of novel antimicrobial agents with new target and selective toxicity towards pathogens. Menaquinone is a component of electron transport chains in a majority of anaerobic bacteria and Gram-positive bacteria. Due to its exclusivity in bacteria, menaquinone is thought to be a potential target for development of therapeutically effective antibacterial agents without side effects. In this review, we summarize inhibitors of menaquinone biosynthesis and antibiotics directly targeting menaquinone in bacteria.</p>
収録刊行物
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- Drug Discoveries & Therapeutics
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Drug Discoveries & Therapeutics 10 (3), 123-128, 2016
特定非営利活動法人 バイオ＆ソーシャル・サイエンス推進国際研究交流会