Radiological and Pathological Correlation in Anti-MDA5 Antibody-positive Interstitial Lung Disease: Rapidly Progressive Perilobular Opacities and Diffuse Alveolar Damage
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- Chino Haruka
- Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, Japan
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- Sekine Akimasa
- Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, Japan
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- Baba Tomohisa
- Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, Japan
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- Iwasawa Tae
- Department of Radiology, Kanagawa Cardiovascular and Respiratory Center, Japan
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- Okudela Koji
- Department of Pathology, Yokohama City University Graduate School of Medicine, Japan
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- Takemura Tamiko
- Department of Pathology, Japanese Red Cross Medical Center, Japan
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- Itoh Harumi
- Biomedical Imaging Research Center, University of Fukui, Japan
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- Sato Shinji
- Division of Rheumatology, Department of Internal Medicine, Tokai University School of Medicine, Japan
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- Suzuki Yasuo
- Division of Rheumatology, Department of Internal Medicine, Tokai University School of Medicine, Japan
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- Ogura Takashi
- Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, Japan
Abstract
<p>We herein present the first case of rapidly progressive interstitial lung disease (RP-ILD) with anti-melanoma differentiation-associated protein 5 (MDA5) antibody evaluated by surgical lung biopsy (SLB). High-resolution CT scan revealed perilobular opacities, which rapidly became thicker and formed consolidation, resulting in remarkable loss of lung volume. Specimens taken from SLB revealed membranous organization with alveolar occlusion, dilation of alveolar ducts, and sacs with collapsed alveoli, which are typical features of diffuse alveolar damage (DAD). Rapidly progressive perilobular opacities may be characteristic of RP-ILD with anti-MDA5 antibody and DAD. </p>
Journal
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- Internal Medicine
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Internal Medicine 55 (16), 2241-2246, 2016
The Japanese Society of Internal Medicine