A Novel Clerodane Diterpene from <i>Vitex cofassus</i>

• Rasyid Faradiba Abdul

  School of Pharmaceutical Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University

• Fukuyoshi Shuichi

  School of Pharmaceutical Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University

• Ando Hirokazu

  School of Pharmaceutical Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University

• Miyake Katsunori

  School of Pharmaceutical Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University

• Atsumi Toshiyuki

  School of Pharmacy, Kyushu University of Health and Welfare

• Fujie Tetsuo

  Advanced Science Research Center, Kanazawa University

• Saito Yohei

  School of Pharmaceutical Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University

• Goto Masuo

  UNC Eshelman School of Pharmacy, University of North Carolina

• Shinya Tomohiro

  School of Pharmacy, Kyushu University of Health and Welfare

• Mikage Masayuki

  Faculty of Agriculture, Tokyo University of Agriculture

• Sasaki Yohei

  School of Pharmaceutical Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University

• Nakagawa-Goto Kyoko

  School of Pharmaceutical Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University UNC Eshelman School of Pharmacy, University of North Carolina

Bibliographic Information

Other Title

• A Novel Clerodane Diterpene from Vitex cofassus

Abstract

New clerodane diterpene, 16-hydroxy-pentandralactone (1) and known diterpene acuminolide (2) were isolated from the methanol extract of Vitex cofassus leaves. The chemical structure and the absolute configuration of 1 were determined by MS, NMR and electron circular dichroism (ECD) experiments. The isolated compounds were evaluated for their antiproliferative activities against a panel of human tumor cell lines, including a multidrug-resistant (MDR) cell line. Both compounds showed potent antiproliferative activities against all the tested cell lines with IC₅₀ values of 5.4–11.4 µM. Their effects on cell viability were also tested using vascular endothelial growth factor (VEGF)-stimulated human umbilical vein endothelial cells (HUVECs). Compound 1 inhibited VEGF-stimulated HUVEC proliferation in a dose-dependent manner. Based on these results, compound 1 could be a candidate for antitumor agent and inhibitor of angiogenesis.

Journal

• Chemical and Pharmaceutical Bulletin

  Chemical and Pharmaceutical Bulletin 65 (1), 116-120, 2017

  The Pharmaceutical Society of Japan

Keywords

• <i>Vitex cofassus</i>
• clerodane diterpene
• antiproliferative activity
• antiangiogenic activity

Details

• CRID: 1390282679154530304
• NII Article ID: 130005187753
• NII Book ID: AA00602100
• DOI: 10.1248/cpb.c16-00775
• ISSN: 13475223
• ISSN: 00092363
• NDL BIB ID: 027820084
• PubMed: 28049908
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I027820084
• Web Site: https://www.jstage.jst.go.jp/article/cpb/65/1/65_c16-00775/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2017254531
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed