Mild Hyperbaric Oxygen Inhibits Growth-related Decrease in Muscle Oxidative Capacity of Rats with Metabolic Syndrome

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Author(s)

    • Takemura Ai
    • Laboratory of Cell Biology and Life Science, Graduate School of Human and Environmental Studies, Kyoto University
    • Ishihara Akihiko
    • Laboratory of Cell Biology and Life Science, Graduate School of Human and Environmental Studies, Kyoto University

Abstract

<p><b><i>Aim</i></b><b>: </b>We examined the effects of mild hyperbaric oxygen on the properties of the soleus muscle in rats with metabolic syndrome.</p><p><b><i>Methods</i></b><b>: </b>Five-week-old metabolic syndrome (SHR/NDmcr-cp, <i>cp/cp</i>) rats were divided into normobaric (CP) and mild hyperbaric oxygen (CP-H) groups (<i>n</i>=5/group). In addition, 5-week-old Wistar rats were assigned as the normobaric control (WR) group (<i>n</i>=5). The CP-H group was exposed to 1.25 atmospheres absolute with 36% oxygen for 3 h daily for 16 weeks. Succinate dehydrogenase (SDH) activity and mRNA levels of peroxisome proliferator-activated receptor γ coactivator-1α (<i>Pgc-1α</i>) in the soleus muscle were examined. The fiber type composition, cross-sectional areas, and SDH staining intensity in the soleus muscle were also examined.</p><p><b><i>Results</i></b><b>: </b>The CP-H group showed lower fasting and nonfasting blood glucose, glycated hemoglobin, total cholesterol, triglyceride, insulin, and systolic blood pressure levels; higher adiponectin levels; and higher SDH activity and mRNA levels of <i>Pgc-1α</i> in the muscle than the CP group. Compared with the CP group, the CP-H group had a lower percentage of type I fibers and observed type IIA fibers in the muscle. The CP-H group also had higher SDH staining intensity of type Ⅰ and type IIC fibers in the muscle than the CP group. No differences in these values were observed in the muscles of the WR and CP-H groups.</p><p><b><i>Conclusion</i></b><b>: </b>Mild hyperbaric oxygen inhibited growth-related increase in blood glucose levels and decrease in muscle oxidative capacity of rats with metabolic syndrome because of improved oxidative metabolism.</p><p></p>

Journal

  • Journal of Atherosclerosis and Thrombosis

    Journal of Atherosclerosis and Thrombosis 24(1), 26-38, 2017

    Japan Atherosclerosis Society

Codes

  • NII Article ID (NAID)
    130005188286
  • Text Lang
    ENG
  • Article Type
    journal article
  • ISSN
    1340-3478
  • Data Source
    IR  J-STAGE 
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