Gas-liquid interfacial plasmas producing reactive species for cell membrane permeabilization
-
- Kaneko Toshiro
- Department of Electronic Engineering, Tohoku University
-
- Sasaki Shota
- Department of Electronic Engineering, Tohoku University
-
- Takashima Keisuke
- Department of Electronic Engineering, Tohoku University
-
- Kanzaki Makoto
- Department of Biomedical Engineering, Tohoku University
この論文をさがす
抄録
<p>Gas-liquid interfacial atmospheric-pressure plasma jets (GLI-APPJ) are used medically for plasma-induced cell-membrane permeabilization. In an attempt to identify the dominant factors induced by GLI-APPJ responsible for enhancing cell-membrane permeability, the concentration and distribution of plasma-produced reactive species in the gas and liquid phase regions are measured. These reactive species are classified in terms of their life-span: long-lived (e.g., H2O2), short-lived (e.g., O2•−), and extremely-short-lived (e.g., •OH). The concentration of plasma-produced •OHaq in the liquid phase region decreases with an increase in solution thickness (<1 mm), and plasma-induced cell-membrane permeabilization is found to decay markedly as the thickness of the solution increases. Furthermore, the horizontally center-localized distribution of •OHaq, resulting from the center-peaked distribution of •OH in the gas phase region, corresponds with the distribution of the permeabilized cells upon APPJ irradiation, whereas the overall plasma-produced oxidizing species such as H2O2aq in solution exhibit a doughnut-shaped horizontal distribution. These results suggest that •OHaq is likely one of the dominant factors responsible for plasma-induced cell-membrane permeabilization.</p>
収録刊行物
-
- Journal of Clinical Biochemistry and Nutrition
-
Journal of Clinical Biochemistry and Nutrition 60 (1), 3-11, 2017
一般社団法人 日本酸化ストレス学会
- Tweet
キーワード
詳細情報 詳細情報について
-
- CRID
- 1390282679647651200
-
- NII論文ID
- 130005188908
-
- ISSN
- 18805086
- 09120009
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- Crossref
- CiNii Articles
- KAKEN
-
- 抄録ライセンスフラグ
- 使用不可