Light Chain Deposition Disease Diagnosed with Laser Micro-dissection, Liquid Chromatography, and Tandem Mass Spectrometry of Nodular Glomerular Lesions
-
- Kasagi Tomomichi
- Division of Nephrology and Rheumatology, Aichi Medical University School of Medicine, Japan
-
- Nobata Hironobu
- Division of Nephrology and Rheumatology, Aichi Medical University School of Medicine, Japan
-
- Suzuki Keisuke
- Division of Nephrology and Rheumatology, Aichi Medical University School of Medicine, Japan
-
- Miura Naoto
- Division of Nephrology and Rheumatology, Aichi Medical University School of Medicine, Japan
-
- Banno Shogo
- Division of Nephrology and Rheumatology, Aichi Medical University School of Medicine, Japan
-
- Takami Akiyoshi
- Division of Hematology, Department of Internal Medicine, Aichi Medical University School of Medicine, Japan
-
- Yamashita Taro
- Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Japan
-
- Ando Yukio
- Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Japan
-
- Imai Hirokazu
- Division of Nephrology and Rheumatology, Aichi Medical University School of Medicine, Japan
この論文をさがす
抄録
<p>A 42-year-old man developed nephrotic syndrome and rapidly progressive renal failure. Kidney biopsy demonstrated nodular glomerulosclerosis, negative Congo red staining, and no deposition of light or heavy chains. Laser micro-dissection and liquid chromatography with tandem mass spectrometry of nodular lesions revealed the presence of a kappa chain constant region and kappa III variable region, which signified light chain deposition disease. Dexamethasone and thalidomide were effective in decreasing the serum levels of free kappa light chain from 147.0 to 38.0 mg/L, eliminating proteinuria, and halting the worsening of the kidney dysfunction, with serum creatinine levels stable around 4.0 mg/dL for 3 years. </p>
収録刊行物
-
- Internal Medicine
-
Internal Medicine 56 (1), 61-66, 2017
一般社団法人 日本内科学会