Folate Deficiency Was Associated with Increased Alanine Aminotransferase and Glutamyl Transpeptidase Concentrations in a Chinese Hypertensive Population: A Cross-Sectional Study

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  • LI Wen-Xing
    Institute of Health Sciences, Anhui University State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences
  • LI Wei
    Center for Stem Cell and Translational Medicine, School of Life Sciences, Anhui University
  • CAO Jia-Qian
    CAS Key Laboratory of Pathogenic Microbiology & Immunology, Institute of Microbiology, Chinese Academy of Sciences University of Chinese Academy of Sciences
  • YAN Haiyue
    Center for Stem Cell and Translational Medicine, School of Life Sciences, Anhui University
  • SUN Yuanyuan
    Center for Stem Cell and Translational Medicine, School of Life Sciences, Anhui University
  • ZHANG Hong
    Center for Stem Cell and Translational Medicine, School of Life Sciences, Anhui University
  • ZHANG Qiang
    Center for Stem Cell and Translational Medicine, School of Life Sciences, Anhui University
  • TANG Ling
    Center for Stem Cell and Translational Medicine, School of Life Sciences, Anhui University
  • WANG Manman
    Center for Stem Cell and Translational Medicine, School of Life Sciences, Anhui University
  • HUANG Jing-Fei
    State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences KIZ-SU Joint Laboratory of Animal Models and Drug Development, College of Pharmaceutical Sciences, Soochow University Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan
  • LIU Dahai
    Center for Stem Cell and Translational Medicine, School of Life Sciences, Anhui University

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Alanine aminotransferase (ALT), aspartate transaminase (AST), and glutamyl transpeptidase (GGT) were three key enzymes in the hepatic metabolism. This study aimed to investigate the effect of homocysteine (Hcy) metabolism gene polymorphisms and serum Hcy and folate level on the hepatic functions in a Chinese hypertensive population. A representative sample with 480 subjects aged 28-75 was enrolled in 2005.9-2005.12 from six hospitals in different Chinese regions. Serum ALT, AST and GGT were measured by using an automatic biochemistry analyzer. Serum Hcy was measured by high-performance liquid chromatography, and serum folate was measured by chemiluminescent immunoassay. Known genotypes were detected by PCR-RFLP methods. The results showed that the MTHFR C677T mutation was related a decreased serum AST level (r=−0.11, p=0.026), whereas the MTHFR A1298C mutation elevated serum AST level (r=0.11, p=0.032). Furthermore, multiple regression analysis showed that folate deficiency was associated with higher serum ALT (β (SE): 0.13 (0.06), p=0.031) and GGT level (β (SE): 0.18 (0.07), p=0.011). However, serum Hcy level may not affect the hepatic functions. Our data suggested that hepatic functions were affected by MTHFR gene polymorphisms and serum folate level. Further studies are needed to confirm these correlations in a larger population.

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