Contribution of Gap Junctions to the Function of the Vascular Endothelium

• Okamoto Takayuki

  Department of Molecular Pathobiology and Cell Adhesion Biology

Bibliographic Information

Other Title

• ギャップジャンクションと血管内皮機能
• ギャップジャンクション ト ケッカン ナイヒ キノウ

Abstract

Gap junctions (GJs) are comprised of members of the connexin (Cx) family and endothelial GJs play an important role in vascular function, stability, and homeostasis. Endothelial cells (ECs) communicate to adjacent ECs, vascular smooth muscle cells, leukocytes and platelets via GJ, thereby Cx–mediated interactions with each type of cells have shown different effects over a wide range of vascular functions. Endothelium regulates vascular inflammation, blood coagulation, vasodilation/ vasoconstriction, angiogenesis, and vascular stiffness. Endothelial dysfunction is related to cardiovascular diseases such as atherosclerosis. The alteration of Cxs expression in vascular component cells contributes to the development of endothelial dysfunction and cardiovascular diseases. We have summarized here the role of GJs in the function of the vascular endothelium.

Journal

• MEMBRANE

  MEMBRANE 41 (2), 61-67, 2016

  THE MEMBRANE SOCIETY OF JAPAN

Keywords

• gap junction
• endothelial function
• endothelial cell
• inflammation
• atherosclerosis

Details

• CRID: 1390001206423334272
• NII Article ID: 130005249085
• NII Book ID: AN0023215X
• DOI: 10.5360/membrane.41.61
• ISSN: 18846440
• ISSN: 03851036
• NDL BIB ID: 027208609
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I027208609
• Web Site: https://www.jstage.jst.go.jp/article/membrane/41/2/41_61/_pdf
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed