Modification of Composite Resin Surface with Carbon Nanotubes Enhances Cell Proliferation

• TANAKA Saori

  Division of General Dentistry Center for Dental Clinics, Department of Periodontology and Endodontology, Hokkaido University Graduate School of Dental Medicine, Sapporo, Japan

• MIYAJI Hirofumi

  Department of Periodontology and Endodontology, Hokkaido University Graduate School of Dental Medicine, Sapporo, Japan

• NISHIDA Erika

  Department of Periodontology and Endodontology, Hokkaido University Graduate School of Dental Medicine, Sapporo, Japan

• INOUE Kana

  Department of Periodontology and Endodontology, Hokkaido University Graduate School of Dental Medicine, Sapporo, Japan

• MIYATA Saori

  Department of Periodontology and Endodontology, Hokkaido University Graduate School of Dental Medicine, Sapporo, Japan

• KATO Akihito

  Department of Periodontology and Endodontology, Hokkaido University Graduate School of Dental Medicine, Sapporo, Japan

• KANAYAMA Izumi

  Department of Periodontology and Endodontology, Hokkaido University Graduate School of Dental Medicine, Sapporo, Japan

• MURAKAMI Shusuke

  Department of Periodontology and Endodontology, Hokkaido University Graduate School of Dental Medicine, Sapporo, Japan

• KAWAMOTO Kohei

  Department of Periodontology and Endodontology, Hokkaido University Graduate School of Dental Medicine, Sapporo, Japan

• FUGETSU Bunshi

  Nano-Agri Lab, Policy Alternatives Research Institute, The University of Tokyo, Tokyo, Japan

• TANAKA Toru

  Department of Restorative Dentistry,

• TAKITA Hiroko

  Support Section for Education and Research, Hokkaido University Graduate School of Dental Medicine, Sapporo, Japan

• IIZUKA Tadashi

  Support Section for Education and Research, Hokkaido University Graduate School of Dental Medicine, Sapporo, Japan

• KAWANAMI Masamitsu

  Department of Periodontology and Endodontology, Hokkaido University Graduate School of Dental Medicine, Sapporo, Japan

Abstract

Composite resin (CR) is used in vivo as a root perforation sealer and as a retrograde obturation material following apicoectomy, but it does not possess adequate biocompatibility. Effective biological modification of the CR surface is thus needed to improve its biocompatibility. Carbon nanotubes (CNTs) are a type of nanocarbon material formed from cylindrical graphene sheets with a diameter of about 10 to 200 nm. CNTs have garnered attention for useful properties such as promoting cell adhesion and proliferation. The present study evaluated cell adhesion and proliferation on CR discs coated with CNTs. CR discs were coated by immersion in a dispersion of CNTs (Nanocyl NC7000, 9.5 nm diameter). The CNT coating was then observed with a scanning electron microscope (SEM) to investigate its surface properties. The effects of CNT coating were also investigated by conducting cell culture assay using osteoblasts. The coating process enabled CNTs to adhere to the resin surface, resulting in good adhesion and spreading of the osteoblasts that indicated a high level of cell proliferation. The study findings showed that coating the surface of CRs with CNTs improved their biocompatibility.

Journal

• Nano Biomedicine

  Nano Biomedicine 8 (1), 27-34, 2016

  Nano Biomedical Society

Keywords

• Carbon nanotubes
• Composite Resin
• Cell proliferation
• Biocompatibility

Details

• CRID: 1390001205346846976
• NII Article ID: 130005249733
• DOI: 10.11344/nano.8.27
• ISSN: 21854734
• ISSN: 18835198
• Text Lang: en
• Data Source:
  • JaLC
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed