担癌状態における骨髄由来抑制細胞(Myeloid derived suppressor cells) の治療による変化  [in Japanese] The effect of treatment for Myeloid derived suppressor cells in tumor bearing host  [in Japanese]

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Author(s)

    • 田中 智子 Tanaka Tomoko
    • 神戸大学大学院医学研究科 外科学講座 食道胃腸外科学分野 Department of Surgery, Division of Gastrointenstinal Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
    • 押切 太郎 Oshikiri Taro
    • 神戸大学大学院医学研究科 外科学講座 食道胃腸外科学分野 Department of Surgery, Division of Gastrointenstinal Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
    • 松田 武 Matsuda Takeru
    • 神戸大学大学院医学研究科 外科学講座 食道胃腸外科学分野 Department of Surgery, Division of Gastrointenstinal Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
    • 角 泰雄 Sumi Yasuo
    • 神戸大学大学院医学研究科 外科学講座 食道胃腸外科学分野 Department of Surgery, Division of Gastrointenstinal Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
    • 中村 哲 Nakamura Tetsu
    • 神戸大学大学院医学研究科 外科学講座 食道胃腸外科学分野 Department of Surgery, Division of Gastrointenstinal Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
    • 鈴木 知志 Suzuki Satoshi
    • 神戸大学大学院医学研究科 外科学講座 食道胃腸外科学分野 Department of Surgery, Division of Gastrointenstinal Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
    • 掛地 吉弘 Kakeji Yoshihiro
    • 神戸大学大学院医学研究科 外科学講座 食道胃腸外科学分野 Department of Surgery, Division of Gastrointenstinal Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
    • 山下 公大 Yamashita Kimihiro
    • 神戸大学大学院医学研究科 外科学講座 食道胃腸外科学分野 Department of Surgery, Division of Gastrointenstinal Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
    • 大坪 大 Otsubo Dai
    • 神戸大学大学院医学研究科 外科学講座 食道胃腸外科学分野 Department of Surgery, Division of Gastrointenstinal Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
    • 有本 聡 Arimoto Akira
    • 神戸大学大学院医学研究科 外科学講座 食道胃腸外科学分野 Department of Surgery, Division of Gastrointenstinal Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
    • 西 将康 Nishi Masayasu
    • 神戸大学大学院医学研究科 外科学講座 食道胃腸外科学分野 Department of Surgery, Division of Gastrointenstinal Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
    • 長谷川 寛 Hasegawa Hiroshi
    • 神戸大学大学院医学研究科 外科学講座 食道胃腸外科学分野 Department of Surgery, Division of Gastrointenstinal Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
    • 山本 将士 Yamamoto Masashi
    • 神戸大学大学院医学研究科 外科学講座 食道胃腸外科学分野 Department of Surgery, Division of Gastrointenstinal Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
    • 金治 新悟 Kanaji Shingo
    • 神戸大学大学院医学研究科 外科学講座 食道胃腸外科学分野 Department of Surgery, Division of Gastrointenstinal Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
    • 松田 佳子 Matsuda Yoshiko
    • 神戸大学大学院医学研究科 外科学講座 食道胃腸外科学分野 Department of Surgery, Division of Gastrointenstinal Surgery, Kobe University Graduate School of Medicine, Kobe, Japan

Abstract

<p>Myeloid derived suppressor cells (MDSCs), a major player for tumor-induced immunosuppression, especially induce antigen-specific CD8-Tcell tolerance and contribute to tumor growth and progression. MDSCs represent a heterogeneous group of cells originated from the myeloid cells. MDSCs accumulate in tumor-bearing mice and cancer patients. Various drugs that directly target MDSCs can improve antitumor immune response. Recent studies have demonstrated MDSCs can be suppressed by certain chemotherapeutic agents, such as 5-Fluorouracil (5-FU), gemcitabin and docetaxel. We hypothesized that treatment by 5-FU or surgical resection of primary tumors would prevent lung metastasis formation by inhibiting MDSCs. These results indicate that early-phase administration of 5-FU and early-phase resection of the primary tumor may provide therapeutic values to prevent MDSC-mediated lung metastases in tumor-bearing host. The results of our study may give a clue to develop a new strategy to control malignant tumors by regulating tumorassociated immune responses. Furthermore, we reviewed current research on the MDSC-targeted therapy.</p>

Journal

  • Cytometry Research

    Cytometry Research 26(2), 27-31, 2016

    Japan Cytometry Society

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