The effect of treatment for Myeloid derived suppressor cells in tumor bearing host

DOI
  • Tanaka Tomoko
    Department of Surgery, Division of Gastrointenstinal Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
  • Yamashita Kimihiro
    Department of Surgery, Division of Gastrointenstinal Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
  • Otsubo Dai
    Department of Surgery, Division of Gastrointenstinal Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
  • Arimoto Akira
    Department of Surgery, Division of Gastrointenstinal Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
  • Nishi Masayasu
    Department of Surgery, Division of Gastrointenstinal Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
  • Hasegawa Hiroshi
    Department of Surgery, Division of Gastrointenstinal Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
  • Yamamoto Masashi
    Department of Surgery, Division of Gastrointenstinal Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
  • Kanaji Shingo
    Department of Surgery, Division of Gastrointenstinal Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
  • Matsuda Yoshiko
    Department of Surgery, Division of Gastrointenstinal Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
  • Oshikiri Taro
    Department of Surgery, Division of Gastrointenstinal Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
  • Matsuda Takeru
    Department of Surgery, Division of Gastrointenstinal Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
  • Sumi Yasuo
    Department of Surgery, Division of Gastrointenstinal Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
  • Nakamura Tetsu
    Department of Surgery, Division of Gastrointenstinal Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
  • Suzuki Satoshi
    Department of Surgery, Division of Gastrointenstinal Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
  • Kakeji Yoshihiro
    Department of Surgery, Division of Gastrointenstinal Surgery, Kobe University Graduate School of Medicine, Kobe, Japan

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Other Title
  • 担癌状態における骨髄由来抑制細胞（Myeloid derived suppressor cells） の治療による変化

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Abstract

<p>Myeloid derived suppressor cells (MDSCs), a major player for tumor-induced immunosuppression, especially induce antigen-specific CD8-Tcell tolerance and contribute to tumor growth and progression. MDSCs represent a heterogeneous group of cells originated from the myeloid cells. MDSCs accumulate in tumor-bearing mice and cancer patients. Various drugs that directly target MDSCs can improve antitumor immune response. Recent studies have demonstrated MDSCs can be suppressed by certain chemotherapeutic agents, such as 5-Fluorouracil (5-FU), gemcitabin and docetaxel. We hypothesized that treatment by 5-FU or surgical resection of primary tumors would prevent lung metastasis formation by inhibiting MDSCs. These results indicate that early-phase administration of 5-FU and early-phase resection of the primary tumor may provide therapeutic values to prevent MDSC-mediated lung metastases in tumor-bearing host. The results of our study may give a clue to develop a new strategy to control malignant tumors by regulating tumorassociated immune responses. Furthermore, we reviewed current research on the MDSC-targeted therapy.</p>

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