The roles of kisspeptin revisited: inside and outside the hypothalamus

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Author(s)

Abstract

<p> Kisspeptin, encoded by <i>KISS1</i>/<i>Kiss1</i> gene, is now considered a master regulator of reproductive functions in mammals owing to its involvement in the direct activation of gonadotropin-releasing hormone (GnRH) neurons after binding to its cognate receptor, GPR54. Ever since the discovery of kisspeptin, intensive studies on hypothalamic expression of <i>KISS1</i>/<i>Kiss1</i> and on physiological roles of hypothalamic kisspeptin neurons have provided clues as to how the brain controls sexual maturation at the onset of puberty and subsequent reproductive performance in mammals. Additionally, emerging evidence indicates the potential involvement of extra-hypothalamic kisspeptin in reproductive functions. Here, we summarize data regarding kisspeptin inside and outside the hypothalamus and revisit the physiological roles of central and peripheral kisspeptins in the reproductive functions of mammals.</p>

Journal

  • Journal of Reproduction and Development

    Journal of Reproduction and Development 62(6), 537-545, 2016

    THE SOCIETY FOR REPRODUCTION AND DEVELOPMENT

Codes

  • NII Article ID (NAID)
    130005251168
  • NII NACSIS-CAT ID (NCID)
    AA10936678
  • Text Lang
    ENG
  • ISSN
    0916-8818
  • NDL Article ID
    027801153
  • NDL Call No.
    Z54-H305
  • Data Source
    NDL  J-STAGE 
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