Effect of 5-Substitution of Uracil Base in DNA Photocrosslinking Using 3-Cyanovinylcarbazole
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Oligonucleotide containing 3-cyanovinylcarbazole (<sup>CNV</sup>K) can crosslink to a pyrimidine base in complementary DNA/RNA by a few seconds of irradiation. The effect of 5-substitution of the uracil base in DNA photocrosslinking using <sup>CNV</sup>K was evaluated. Each uracil analog base had diverse photoreactivity with <sup>CNV</sup>K, and there was good correlation with the photoreactivity and LUMO level of the target uracil base in duplex DNA.
- Chemistry Letters
Chemistry Letters 45(8), 887-889, 2016
The Chemical Society of Japan