Effect of 5-Substitution of Uracil Base in DNA Photocrosslinking Using 3-Cyanovinylcarbazole

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Author(s)

    • Kawabata Hayato
    • School of Materials Science, Japan Advanced Institute Science and Technology
    • Muramatsu Hodaka
    • School of Materials Science, Japan Advanced Institute Science and Technology
    • Fujimoto Kenzo
    • School of Materials Science, Japan Advanced Institute Science and Technology

Abstract

Oligonucleotide containing 3-cyanovinylcarbazole (<sup>CNV</sup>K) can crosslink to a pyrimidine base in complementary DNA/RNA by a few seconds of irradiation. The effect of 5-substitution of the uracil base in DNA photocrosslinking using <sup>CNV</sup>K was evaluated. Each uracil analog base had diverse photoreactivity with <sup>CNV</sup>K, and there was good correlation with the photoreactivity and LUMO level of the target uracil base in duplex DNA.

Journal

  • Chemistry Letters

    Chemistry Letters 45(8), 887-889, 2016

    The Chemical Society of Japan

Codes

  • NII Article ID (NAID)
    130005254533
  • Text Lang
    ENG
  • ISSN
    0366-7022
  • Data Source
    J-STAGE 
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