Immunotoxic Effect of Low-Dose Methylmercury Is Negligible in Mouse Models of Ovalbumin or Mite-Induced Th2 Allergy

• Nakamura Ryosuke

  Department of Public Health, School of Pharmacy, Kitasato University

• Takanezawa Yasukazu

  Department of Public Health, School of Pharmacy, Kitasato University

• Sone Yuka

  Department of Public Health, School of Pharmacy, Kitasato University

• Uraguchi Shimpei

  Department of Public Health, School of Pharmacy, Kitasato University

• Sakabe Kou

  Department of Human Structure and Function, Tokai University School of Medicine

• Kiyono Masako

  Department of Public Health, School of Pharmacy, Kitasato University

抄録

Methylmercury (MeHg) is one of the most toxic environmental pollutants and presents a serious hazard to health worldwide. Although the adverse effects of MeHg, including neurotoxicity, have been studied, its effects on immune function, in particular the immune response, remain unclear. This study examined the effects of low-dose MeHg on immune responses in mice. Mice were orally immunized with ovalbumin (OVA) or subcutaneously injected with mite extract to induce a T-helper 2 (Th2) allergic response. They were then exposed to MeHg (0, 0.02, 1.0, or 5.0 mg·kg⁻¹·d⁻¹). Immunization with oral OVA or subcutaneous mite extract increased serum levels of OVA-specific immunoglobulin (Ig) E (OVA-IgE), OVA-IgG1, interleukin (IL)-4, and IL-13, and total IgE, total IgG, and IL-13 when compared with levels in non-immunized mice. However, no interferon (IFN)-γ was detected. By contrast, serum levels of OVA-IgE, OVA-IgG1, IL-4, and IL-13, or total IgE, total IgG, and IL-13 in Th2 allergy model mice subsequently treated with MeHg were no higher than those in MeHg-untreated mice. These results suggest that MeHg exposure has no adverse effects on Th2 immune responses in antigen-immunized mice.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 39 (8), 1353-1358, 2016

  公益社団法人 日本薬学会

キーワード

• methylmercury
• low-dose
• T-helper 2 (Th2) allergic response
• ovalbumin-induced allergy model
• mite-induced allergy model

詳細情報

• CRID: 1390282679608078848
• NII論文ID: 130005254666
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.b16-00306
• ISSN: 13475215
• ISSN: 09186158
• NDL書誌ID: 027523103
• PubMed: 27476942
• Web Site: http://id.ndl.go.jp/bib/027523103
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I027523103
• Web Site: https://www.jstage.jst.go.jp/article/bpb/39/8/39_b16-00306/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2017306829
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可