Serum ferritin and high sensitivity C-reactive protein are associated with metabolic syndrome in Japanese men and women

• YAMADA Chizumi

  Tokai University Tokyo Hospital Department of Clinical Health Science, Tokai University School of Medicine

• KISHIMOTO Noriaki

  Tokai University Tokyo Hospital Department of Clinical Health Science, Tokai University School of Medicine

• YUKUMATSU Nobushige

  Department of Clinical Health Science, Tokai University School of Medicine Life Care Center, Graduate School of Medicine, Tokai University

• TAKEDA Asami

  Tokai University Tokyo Hospital Department of Clinical Health Science, Tokai University School of Medicine

• OGATA Tamae

  Tokai University Tokyo Hospital Department of Clinical Health Science, Tokai University School of Medicine

• KIKUCHI Emiko

  Tokai University Tokyo Hospital Department of Clinical Health Science, Tokai University School of Medicine

• KURODA Emiko

  Tokai University Tokyo Hospital

• MOTEGI Shigeyuki

  Tokai University Tokyo Hospital

• ISHII Naoaki

  Department of Clinical Health Science, Tokai University School of Medicine Life Care Center, Graduate School of Medicine, Tokai University

• NISHIZAKI Yasuhiro

  Tokai University Tokyo Hospital Department of Clinical Health Science, Tokai University School of Medicine Life Care Center, Graduate School of Medicine, Tokai University

Abstract

 Objective Ferritin is involved in the occurrence of oxidative stress and regulation of adiponectin, both of which can modulate metabolic syndrome (MetS). To investigate the association of ferritin with MetS in Japanese, a cross-sectional study was conducted involving 324 men and 340 women who underwent anti-aging health checks at Tokai University Tokyo Hospital.<br> Methods The MetS criteria of the Japanese Society of Internal Medicine was used and the levels of serum ferritin and high sensitivity C-reactive protein (hsCRP) were compared with or without MetS-related abnormalities (abdominal obesity, waist circumference ≥ 85 cm in men and ≥ 90 cm in women; hypertension, systolic BP ≥ 130 and/or diastolic BP ≥ 85 mmHg; hyperglycemia, fasting glucose ≥ 110 mg/dL; and dyslipidemia, triglycerides ≥ 150 mg/dL and/or HDL-C < 40 mg/dL).<br> Results Ferritin levels were significantly higher in the subjects with hyperglycemia and dyslipidemia in both men and women, and in those with abdominal obesity in women. HsCRP levels were significantly higher in the subjects with abdominal obesity in both sexes, and in those with hypertension in men. Serum ferritin increased in proportion to the number of MetS components and was significantly higher in MetS subjects than in non-MetS counterparts in both men and women, although these results were not obtained regarding hsCRP.<br> Conclusion Ferritin is not considered inferior compared with the well-known marker hsCRP with respect to the association with MetS. High serum ferritin concentrations could potentially be used as a biomarker for MetS as well as hsCRP.

Journal

• Health Evaluation and Promotion

  Health Evaluation and Promotion 43 (4), 511-517, 2016

  Japan Society of Health Evaluation and Promotion

Keywords

• Ferritin
• high sensitivity C-reactive protein (hsCRP)
• metabolic syndrome (MetS)
• anti-aging health checkup system

Details

• CRID: 1390001205198264704
• NII Article ID: 130005254933
• DOI: 10.7143/jhep.43.511
• ISSN: 18844103
• ISSN: 13470086
• Web Site: https://www.jstage.jst.go.jp/article/jhep/43/4/43_511/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2016178512
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed