ハリネズミは化学物質高感受性種？African hedgehog (Atalerix albiventris)で観察された低薬物代謝能

• アクソルン サエンティエンチャイ

  北海道大学大学院獣医学研究科毒性学教室 カセサート大学

• 池中 良徳

  北海道大学大学院獣医学研究科毒性学教室 ノースウェスト大学

• ネスタ サム

  北海道大学大学院獣医学研究科毒性学教室

• ウスマ ジャムナーク

  カセサート大学

• 水川 葉月

  北海道大学大学院獣医学研究科

• 中山 翔太

  北海道大学大学院獣医学研究科毒性学教室

• 石塚 真由美

  北海道大学大学院獣医学研究科毒性学教室

書誌事項

タイトル別名

• Is hedgehog high sensitive to xenobiotics? Low metabolism enzyme activities observed in African hedgehog (Atalerix albiventris)

抄録

African hedgehog, Atalerix albiventris, is a spiny mammal which becomes famous exotic pet in many counties. In order to elucidate xenobiotic metabolisms ability of hedgehogs, pyrene, one of the typical polycyclic aromatic hydrocarbon were exposed. From in vivo exposure study, pyrene was biotransformed to glucuronide and sulfate conjugates such as pyrene-1-glucuronide, pyrene-1-sulfate, and pyrenediol-sulfate and excreted to urine. Pyrene-1-glucuronide was main metabolite and limited excretion of sulfate conjugates were observed. Based on the results of in vivo exposure study, in vitro enzymatic kinetic experiments were performed by using various substrate and compare to rat and pig. Enzyme efficiency of cytochrome P450 (CYP) mediated Ethoxyresorufin O-deethylase activity, and warfarin 4'-, 6-, and 8-hydroxylation activity in hedgehogs were lower than that of rats. Furthermore, UDP-glucuronosyltransferase activities in hedgehogs were also lower Km than that of rats. Interestingly, the enzymatic efficiency of sulfation in hedgehogs was significantly lower than that of rats, whereas hedgehogs had similar sulfation ability as in pigs. Sulfation of hedgehogs may be limit activity in xenobiotic metabolism.

収録刊行物

• 日本毒性学会学術年会

  日本毒性学会学術年会 43.1 (0), P-237-, 2016

  日本毒性学会

詳細情報

• CRID: 1390001205546779904
• NII論文ID: 130005260768
• DOI: 10.14869/toxpt.43.1.0_p-237
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可