ANTXR-1 and -2 independent modulation of a cytotoxicity mediated by anthrax toxin in human cells

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Author(s)

    • FUJIKURA Daisuke FUJIKURA Daisuke
    • Division of Infection and Immunity, Research Center for Zoonosis Control, Hokkaido University, Kita-20, Nishi-10, Kita-ku, Sapporo, Hokkaido 001–0020, Japan
    • TOYOMANE Kochi TOYOMANE Kochi
    • Division of Infection and Immunity, Research Center for Zoonosis Control, Hokkaido University, Kita-20, Nishi-10, Kita-ku, Sapporo, Hokkaido 001–0020, Japan
    • KAMIYA Kozue KAMIYA Kozue
    • Division of Infection and Immunity, Research Center for Zoonosis Control, Hokkaido University, Kita-20, Nishi-10, Kita-ku, Sapporo, Hokkaido 001–0020, Japan
    • MUTOH Memi MUTOH Memi
    • Division of Infection and Immunity, Research Center for Zoonosis Control, Hokkaido University, Kita-20, Nishi-10, Kita-ku, Sapporo, Hokkaido 001–0020, Japan
    • MIFUNE Etsuko MIFUNE Etsuko
    • Division of Infection and Immunity, Research Center for Zoonosis Control, Hokkaido University, Kita-20, Nishi-10, Kita-ku, Sapporo, Hokkaido 001–0020, Japan
    • OHNUMA Miyuki OHNUMA Miyuki
    • Division of Infection and Immunity, Research Center for Zoonosis Control, Hokkaido University, Kita-20, Nishi-10, Kita-ku, Sapporo, Hokkaido 001–0020, Japan
    • HIGASHI Hideaki HIGASHI Hideaki
    • Division of Infection and Immunity, Research Center for Zoonosis Control, Hokkaido University, Kita-20, Nishi-10, Kita-ku, Sapporo, Hokkaido 001–0020, Japan

Abstract

<p>Several animal models have shown that anthrax toxin (ATX) elicits a cytotoxic effect on host cells through anthrax toxin receptor (ANTXR) function. In this study, compared with mouse cells, cells obtained from humans exhibited low sensitivity to ATX-mediated cytotoxicity, and the sensitivity was not correlated with expression levels of ANTXRs. ATX treatment also induced a cytotoxic effect in other cultured human cells, human embryonic kidney (HEK) 293 cells, that express ANTXRs at undetectable levels. Furthermore, ectopic expression of ANTXRs in HEK293 cells did not affect the sensitivity to ATX treatment. These findings suggest that there is an ANTXR-independent cytotoxic mechanism in human cells.</p>

Journal

  • Journal of Veterinary Medical Science

    Journal of Veterinary Medical Science 78(8), 1311-1317, 2016

    JAPANESE SOCIETY OF VETERINARY SCIENCE

Codes

  • NII Article ID (NAID)
    130005261508
  • NII NACSIS-CAT ID (NCID)
    AA10796138
  • Text Lang
    ENG
  • ISSN
    0916-7250
  • NDL Article ID
    027626883
  • NDL Call No.
    Z18-350
  • Data Source
    NDL  J-STAGE 
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