Heavy Alcohol Consumption is Associated with Impaired Endothelial Function:

• Tanaka Aoi

  Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine

• Cui Renzhe

  Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine

• Kitamura Akihiko

  Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine Osaka Center for Cancer and Cardiovascular Diseases Prevention

• Liu Keyang

  Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine

• Imano Hironori

  Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine Osaka Center for Cancer and Cardiovascular Diseases Prevention

• Yamagishi Kazumasa

  Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba

• Kiyama Masahiko

  Osaka Center for Cancer and Cardiovascular Diseases Prevention

• Okada Takeo

  Osaka Center for Cancer and Cardiovascular Diseases Prevention

• Iso Hiroyasu

  Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine

• for the CIRCS Investigators

書誌事項

タイトル別名

• The Circulatory Risk in Communities Study (CIRCS)

抄録

Aim: Previous studies have reported that moderate alcohol consumption is protective against cardiovascular disease, but heavy alcohol consumption increases its risk. Endothelial dysfunction is hypothesized to contribute to the development of atherosclerosis and cardiovascular disease. However, few population-based studies have examined a potential effect of alcohol consumption on endothelial function. Methods: This study included 404 men aged 30–79 years who were recruited from residents in 2 communities under the Circulatory Risk in Communities Study in 2013 and 2014. We asked the individuals about the frequency and volume of alcohol beverages and converted the data into grams of ethanol per day. Endothelial function was assessed by brachial artery flow-mediated dilation (FMD) measurements during reactive hyperemia. We performed cross-sectional analysis of alcohol consumption and %FMD by logistic regression analysis, adjusting for age, baseline brachial artery diameter, body mass index, systolic blood pressure, low-density lipoprotein cholesterol, HbA1c, smoking, antihypertensive medication use, and community. Results: Individuals who drank ≥ 46 g/day ethanol had a lower age-adjusted mean %FMD than non-drinkers (p＜0.01). Compared with non-drinkers, the age-adjusted odds ratios (ORs) (95% confidence interval) of low %FMD (＜5.3%) for former, light (＜23.0 g/day ethanol), moderate (23.0–45.9 g/day ethanol), and heavy (≥ 46.0 g/day ethanol) drinkers were 1.61 (0.67–3.89), 0.84 (0.43–1.66), 1.09 (0.52–2.25), and 2.99 (1.56–5.70), respectively. The corresponding multivariable-adjusted ORs were 1.76 (0.69–4.50), 0.86 (0.42–1.76), 0.98 (0.45–2.12), and 2.39 (1.15–4.95), respectively. Conclusions: Heavy alcohol consumption may be an independent risk factor of endothelial dysfunction in Japanese men.

収録刊行物

• Ｊｏｕｒｎａｌ　ｏｆ　Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ　ａｎｄ　Ｔｈｒｏｍｂｏｓｉｓ

  Ｊｏｕｒｎａｌ　ｏｆ　Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ　ａｎｄ　Ｔｈｒｏｍｂｏｓｉｓ 23 (9), 1047-1054, 2016

  一般社団法人 日本動脈硬化学会

キーワード

• Alcohol consumption
• Endothelial function
• Japanese men
• Cross-sectional study

詳細情報

• CRID: 1390282679410291328
• NII論文ID: 130005261986
• NII書誌ID: AA11018976
• DOI: 10.5551/jat.31641
• ISSN: 18803873
• ISSN: 13403478
• HANDLE: 2241/00144382
• PubMed: 27025680
• Web Site: https://tsukuba.repo.nii.ac.jp/records/39679
• Web Site: https://www.jstage.jst.go.jp/article/jat/23/9/23_31641/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2017191447
• 本文言語コード: en
• データソース種別:
  • JaLC
  • IRDB
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可