p62/SQSTM1を基軸とした新たな肝臓・肝細胞保護・機能維持メカニズム

DOI
  • 尾崎 倫孝
    北海道大学大学院　保健科学研究院　生体分子・機能イメージング部門
  • 芳賀 早苗
    北海道大学大学院　保健科学研究院　生体分子・機能イメージング部門

書誌事項

タイトル別名
  • A new strategy for organ preservation by p62/SQSTM1

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抄録

We have been investigating the mechanism of liver regeneration and injury for liver surgery and transplantation. We firstly studied, in normal liver, the central role of IL-6/Jak/STAT3 in post-PH mitotic response and protective mechanism from hepatocyte injury, and the essential role of PDK1/Akt in post-PH cell growth in case where mitotic response is impaired. In fatty liver, reduced expression of p62/SQSTM1 plays a crucial role in post-hepatectomy acute injury and delayed regeneration with enhanced oxidative stress- and death signal-mediated injury. Reduced expression of p62/SQSTM1 lead to FasL/Fas overexpression and suppressed antioxidant genes through Nrf-2 inactivation, which along with the hypo-responsiveness of Akt, caused post-hepatectomy necrotic/apoptotic liver injury and delayed regeneration. Our study importantly suggests the potential role of p62/SQSTM1 in protecting the liver from all kinds of injury, providing pro-survival property to hepatocytes/liver. Here, we report the pivotal roles of p62/SQSTM1 as a key player for cell/organ preservation, and the potential application for liver preservation and transplantation.

収録刊行物

  • Organ Biology

    Organ Biology 23 (2), 168-172, 2016

    一般社団法人　日本臓器保存生物医学会

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