Preparation of Conjugated Linoleic Acid Microemulsions and their Biodistribution

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  • Kishita Kazuaki
    Interdisciplinary Graduate School of Agriculture and Engineering, University of Miyazaki
  • Ibaraki Kayo
    Faculty of Agriculture, University of Miyazaki
  • Itakura Shoko
    Faculty of Agriculture, University of Miyazaki
  • Yamasaki Yumi
    Faculty of Regional Innovation, University of Miyazaki
  • Nishikata Naoko
    Miyazaki Prefecture Industrial Technology Center
  • Yamamoto Kenji
    Miyazaki Prefecture Industrial Technology Center
  • Shimizu Masataka
    Miyazaki Prefecture Industrial Technology Center
  • Nishiyama Kazuo
    Interdisciplinary Graduate School of Agriculture and Engineering, University of Miyazaki Faculty of Agriculture, University of Miyazaki
  • Yamasaki Masao
    Interdisciplinary Graduate School of Agriculture and Engineering, University of Miyazaki Faculty of Agriculture, University of Miyazaki

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Abstract

<p>Conjugated linoleic acid (CLA) has several beneficial biological properties. Specifically, trans10, cis12-CLA, one of the CLA isomers, has strong physiologic activity against cancer and obesity. However, compared with cis9, trans11-CLA, a naturally occurring CLA isomer, trans10, cis12-CLA tends to be easily metabolized. Therefore, to make efficient use of its biological properties, it is necessary to overcome the rapid clearance of trans10, cis12-CLA from the blood. Here, we employed premix membrane emulsification to prepare two oil-in-water CLA microemulsions (CLA-ME), 100 nm CLA-ME and 200 nm CLA-ME, and investigated their pharmacokinetics in a mouse model. We report that 100 nm CLA-ME contributed to the concentration of blood CLA for longer than 200 nm CLA-ME, indicating that small CLA microparticles were more suitable for maintaining blood trans10, cis12-CLA levels in vivo. However, both CLA-ME could be hardly detected in blood and other tissues 24 h after administration, suggesting that additional strategies for prolonging CLA-ME half-life are required.</p>

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