Time-dependent Changes of Atherosclerotic LDL Complexes after Smoking Cessation
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- Komiyama Maki
- Clinical Research Institute, National Hospital Organization Kyoto Medical Center
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- Shimada Sayaka
- Clinical Research Institute, National Hospital Organization Kyoto Medical Center
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- Wada Hiromichi
- Clinical Research Institute, National Hospital Organization Kyoto Medical Center
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- Yamakage Hajime
- Clinical Research Institute, National Hospital Organization Kyoto Medical Center
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- Satoh-Asahara Noriko
- Clinical Research Institute, National Hospital Organization Kyoto Medical Center
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- Shimatsu Akira
- Clinical Research Institute, National Hospital Organization Kyoto Medical Center
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- Akao Masaharu
- Clinical Research Institute, National Hospital Organization Kyoto Medical Center
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- Morimoto Tatsuya
- Division of Molecular Medicine, School of Pharmaceutical Sciences, University of Shizuoka
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- Takahashi Yuko
- Health Care Center, Nara Women's University
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- Hasegawa Koji
- Clinical Research Institute, National Hospital Organization Kyoto Medical Center
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Abstract
<p>Aim: The α1-antitrypsin–low-density lipoprotein complex (AT-LDL) and serum amyloid A-LDL complex (SAA-LDL) are oxidatively modified LDL complexes that promote atherosclerosis. The serum levels of AT-LDL and SAA-LDL are suggested to be increased by obesity and smoking. We have previously demonstrated that larger weight gain after smoking cessation (SC) perturbs a decrease in the serum level of AT-LDL at 3 months after SC. However, changes of these atherosclerotic makers ＞3 months after SC are unknown. This study investigated post-SC time-dependent changes in two atherogenic lipoproteins, AT-LDL and SAA-LDL, and in the extent of abdominal obesity.</p><p>Methods: In 50 outpatients who had continued SC for 1 year, we measured serum AT-LDL and SAA-LDL levels by the enzyme-linked immunosorbent assay before SC, and at 3 months and 1 year after SC.</p><p>Results: Both body mass index and waist circumstance significantly increased from pre-SC to 3 months after SC and from 3 months after SC to 1 year after SC. Although the serum levels of AT-LDL and SAA-LDL were unchanged from pre-SC to 3 months after SC, these levels decreased significantly from 3 months after SC to 1 year after SC.</p><p>Conclusions: The extent of abdominal obesity and levels of two atherogenic lipoproteins time-dependently change after SC. Although abdominal obesity progressively worsened after SC, the beneficial effect of non-smoking overcomes the potential vascular risks by cessation-associated obesity at 1 year after SC. </p><p></p>
Journal
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- Journal of Atherosclerosis and Thrombosis
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Journal of Atherosclerosis and Thrombosis 23 (11), 1270-1275, 2016
Japan Atherosclerosis Society
